Current challenges in islet transplantation

Cristiane B. Leitão, Pablo Cure, Thipaporn Tharavanij, David Baidal, Rodolfo Alejandro

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Allogeneic islet transplantation is becoming a treatment option for patients with unstable type 1 diabetes melitus (T1DM). Around 80% of the islet recipients achieve insulin independence after one or two islet infusions under "Edmonton-like" immunosuppressive protocol, but only 10% will remain insulin independent over the long term. Islet transplantation leads to glucose stabilization, and severe hypoglycemia is prevented even in patients back on insulin injections. Thus, islet transplantation has achieved the proposed targets in patients with unstable T1DM: normalizing blood glucose and hemoglobin A1c, preventing severe hypoglycemic episodes, and improving quality of life. The current aims of islet transplantation programs are to maintain the success achieved and to overcome remaining obstacles and limitations.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalCurrent Diabetes Reports
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2008

Fingerprint

Islets of Langerhans Transplantation
Insulin
Type 1 Diabetes Mellitus
Homologous Transplantation
Immunosuppressive Agents
Hypoglycemia
Hypoglycemic Agents
Blood Glucose
Hemoglobins
Quality of Life
Glucose
Injections
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Current challenges in islet transplantation. / Leitão, Cristiane B.; Cure, Pablo; Tharavanij, Thipaporn; Baidal, David; Alejandro, Rodolfo.

In: Current Diabetes Reports, Vol. 8, No. 4, 01.08.2008, p. 324-331.

Research output: Contribution to journalArticle

Leitão, Cristiane B. ; Cure, Pablo ; Tharavanij, Thipaporn ; Baidal, David ; Alejandro, Rodolfo. / Current challenges in islet transplantation. In: Current Diabetes Reports. 2008 ; Vol. 8, No. 4. pp. 324-331.
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