Current assessment of heart rate variability and QTc interval length in HIV/AIDS

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Purpose of review The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. Recent findings Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction. Summary These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV.

Original languageEnglish (US)
Pages (from-to)528-533
Number of pages6
JournalCurrent Opinion in HIV and AIDS
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2017

Fingerprint

Acquired Immunodeficiency Syndrome
Heart Rate
HIV
Comorbidity
Cardiac Arrhythmias
Electrocardiography
Chronic Disease
Cardiovascular Diseases
Drug Therapy
Therapeutics
Research

Keywords

  • heart rate variability
  • HIV/AIDS
  • inflammation
  • QTc prolongation
  • VO max

ASJC Scopus subject areas

  • Immunology
  • Hematology
  • Oncology
  • Oncology(nursing)
  • Infectious Diseases
  • Virology

Cite this

Current assessment of heart rate variability and QTc interval length in HIV/AIDS. / McIntosh, Roger C; Lobo, Judith D.; Hurwitz, Barry.

In: Current Opinion in HIV and AIDS, Vol. 12, No. 6, 01.11.2017, p. 528-533.

Research output: Contribution to journalReview article

@article{78e216ccf7a5457ea6b73612dceaf3f4,
title = "Current assessment of heart rate variability and QTc interval length in HIV/AIDS",
abstract = "Purpose of review The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. Recent findings Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction. Summary These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV.",
keywords = "heart rate variability, HIV/AIDS, inflammation, QTc prolongation, VO max",
author = "McIntosh, {Roger C} and Lobo, {Judith D.} and Barry Hurwitz",
year = "2017",
month = "11",
day = "1",
doi = "10.1097/COH.0000000000000408",
language = "English (US)",
volume = "12",
pages = "528--533",
journal = "Current Opinion in HIV and AIDS",
issn = "1746-630X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Current assessment of heart rate variability and QTc interval length in HIV/AIDS

AU - McIntosh, Roger C

AU - Lobo, Judith D.

AU - Hurwitz, Barry

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose of review The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. Recent findings Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction. Summary These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV.

AB - Purpose of review The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. Recent findings Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction. Summary These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV.

KW - heart rate variability

KW - HIV/AIDS

KW - inflammation

KW - QTc prolongation

KW - VO max

UR - http://www.scopus.com/inward/record.url?scp=85027556237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027556237&partnerID=8YFLogxK

U2 - 10.1097/COH.0000000000000408

DO - 10.1097/COH.0000000000000408

M3 - Review article

C2 - 28984702

AN - SCOPUS:85027556237

VL - 12

SP - 528

EP - 533

JO - Current Opinion in HIV and AIDS

JF - Current Opinion in HIV and AIDS

SN - 1746-630X

IS - 6

ER -