Current and future management of acute exacerbations of chronic obstructive pulmonary disease

P. M.A. Calverley, S. Rennard, A. G.N. Agusti, N. Anthonisen, B. Celli, M. Cosio, W. MacNee, R. Rodriguez-Roisin, A. Rossi, A. Wanner, E. Wouters

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are common and associated with significant morbidity and mortality. As acute exacerbations of COPD are difficult to define and their pathogenesis is poorly understood, it is not surprising that their management varies considerably. In this review the current knowledge of the pathophysiology of acute exacerbations of COPD is examined from the perspective of cellular events, blood gases and lung function. Issues involved with management of this condition are also considered, including drug treatment and mechanical ventilation. Finally, five areas for future research are discussed.

Original languageEnglish (US)
Pages (from-to)193-205
Number of pages13
JournalEuropean Respiratory Review
Volume9
Issue number67
StatePublished - Jan 1 1999

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Keywords

  • Acute respiratory failure
  • Drug treatment
  • Expiratory airflow limitation
  • Lung diseases obstructive
  • Mechanical ventilation
  • Pathophysiology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Calverley, P. M. A., Rennard, S., Agusti, A. G. N., Anthonisen, N., Celli, B., Cosio, M., MacNee, W., Rodriguez-Roisin, R., Rossi, A., Wanner, A., & Wouters, E. (1999). Current and future management of acute exacerbations of chronic obstructive pulmonary disease. European Respiratory Review, 9(67), 193-205.