Curare blocks cationic conductance in artificial membranes containing hydrophobic proteins from cholinergic tissues

N. C. Adragna, P. J.I. Salas, M. Parisi, E. De Robertis

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The permeability properties of control artificial lipidic membranes containing synthetic lipids were compared with those made with the lipids and hydrophobic proteins(i.e. proteolipids) extracted from electroplax of Electrophorus electricus and cat heart ventricle. While the controls did not show ionic selectivity the others showed a cationic conductance for Na+ and K+ giving rise to a diffusion potential, which was inhibited by 10-4Md-tubocurarine. It is suggested that proteolipids are responsible for this cationic conductance.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalBiochemical and biophysical research communications
Volume62
Issue number1
DOIs
StatePublished - Jan 6 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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