Cultured canine synovial cells solubilize 45Ca‐labeled hydroxyapatite crystals

Richard W. Evans, Herman S. Cheung, Daniel J. Mccarty

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Microaggregates of hydroxyapatite crystals (HA) have been found in synovial fluid from patients with a variety of joint diseases. Since these crystals may play a pathogenetic role, we wanted to determine whether synovial lining cells degrade HA. The authors report here an in vitro model of HA degradation and find that cultured dog synovial lining cells solubilize 45Ca-labeled HA.

Original languageEnglish (US)
Pages (from-to)829-832
Number of pages4
JournalArthritis & Rheumatism
Issue number7
StatePublished - Jul 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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