CTX-M β-lactamase production and virulence of Escherichia coli K1

Damien Dubois, Nemani V. Prasadarao, Rahul Mittal, Laurent Bret, Marie Roujou-Gris, Richard Bonnet

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.

Original languageEnglish (US)
Pages (from-to)1988-1990
Number of pages3
JournalEmerging infectious diseases
Issue number12
StatePublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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