CSF somatostatin in Alzheimer's disease and major depression

Relationship to hypothalamic-pituitary-adrenal axis and clinical measures

Susan E. Molchan, James L. Hill, Rick A. Martinez, Brian A. Lawlor, Alan M. Mellow, David R. Rubinow, Garth Bissette, Charles Nemeroff, Trey Sunderland

Research output: Contribution to journalArticle

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Abstract

Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased concentrations of cerebrospinal fluid (CSF) somatostatin-like immunoreactivity (SLI), which may be related to alterations in the hypothalamic-pituitary-adrenal axis activity. As in prior studies, we found that CSF SLI was significantly decreased in a group of AD patients (N = 49) and a group of elderly patients with major depression (N = 18), as compared with 13 age-matched controls (F[2, 77] = 12.9, p < .001). In the present study, CSF SLI and CSF corticotropin-releasing factor correlated significantly within the group of AD patients (r = 0.49, p < .0004) and almost attained significance in the depressed patients (r = 0.47, p < .07). CSF SLI correlated significantly with urinary free cortisol within each patient group (r = -0.51, p < .03). Clinical measures of dementia severity and depression did not consistently correlate with CSF SLI in either patient group.

Original languageEnglish
Pages (from-to)509-519
Number of pages11
JournalPsychoneuroendocrinology
Volume18
Issue number7
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Somatostatin
Cerebrospinal Fluid
Alzheimer Disease
Depression
Biomarkers
Corticotropin-Releasing Hormone
Dementia
Hydrocortisone
somatostatin-like peptides

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Molchan, S. E., Hill, J. L., Martinez, R. A., Lawlor, B. A., Mellow, A. M., Rubinow, D. R., ... Sunderland, T. (1993). CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures. Psychoneuroendocrinology, 18(7), 509-519. https://doi.org/10.1016/0306-4530(93)90044-L

CSF somatostatin in Alzheimer's disease and major depression : Relationship to hypothalamic-pituitary-adrenal axis and clinical measures. / Molchan, Susan E.; Hill, James L.; Martinez, Rick A.; Lawlor, Brian A.; Mellow, Alan M.; Rubinow, David R.; Bissette, Garth; Nemeroff, Charles; Sunderland, Trey.

In: Psychoneuroendocrinology, Vol. 18, No. 7, 01.01.1993, p. 509-519.

Research output: Contribution to journalArticle

Molchan, Susan E. ; Hill, James L. ; Martinez, Rick A. ; Lawlor, Brian A. ; Mellow, Alan M. ; Rubinow, David R. ; Bissette, Garth ; Nemeroff, Charles ; Sunderland, Trey. / CSF somatostatin in Alzheimer's disease and major depression : Relationship to hypothalamic-pituitary-adrenal axis and clinical measures. In: Psychoneuroendocrinology. 1993 ; Vol. 18, No. 7. pp. 509-519.
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