CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia

J. W. Stoerner, I. J. Butler, F. H. Morriss, R. Howell, W. E. Seifert, R. M. Caprioli, E. W. Adcock IIIrd, S. E. Denson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.

Original languageEnglish
Pages (from-to)492-494
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume134
Issue number5
StatePublished - Aug 22 1980
Externally publishedYes

Fingerprint

Tyrosinemias
Ascorbic Acid
Neurotransmitter Agents
Homovanillic Acid
Lethargy
Hydroxyindoleacetic Acid
Hypothermia
Tyrosine
Cerebrospinal Fluid
Dopamine
Serotonin
Newborn Infant
Brain
Serum
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Stoerner, J. W., Butler, I. J., Morriss, F. H., Howell, R., Seifert, W. E., Caprioli, R. M., ... Denson, S. E. (1980). CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia. American Journal of Diseases of Children, 134(5), 492-494.

CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia. / Stoerner, J. W.; Butler, I. J.; Morriss, F. H.; Howell, R.; Seifert, W. E.; Caprioli, R. M.; Adcock IIIrd, E. W.; Denson, S. E.

In: American Journal of Diseases of Children, Vol. 134, No. 5, 22.08.1980, p. 492-494.

Research output: Contribution to journalArticle

Stoerner, JW, Butler, IJ, Morriss, FH, Howell, R, Seifert, WE, Caprioli, RM, Adcock IIIrd, EW & Denson, SE 1980, 'CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia', American Journal of Diseases of Children, vol. 134, no. 5, pp. 492-494.
Stoerner JW, Butler IJ, Morriss FH, Howell R, Seifert WE, Caprioli RM et al. CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia. American Journal of Diseases of Children. 1980 Aug 22;134(5):492-494.
Stoerner, J. W. ; Butler, I. J. ; Morriss, F. H. ; Howell, R. ; Seifert, W. E. ; Caprioli, R. M. ; Adcock IIIrd, E. W. ; Denson, S. E. / CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia. In: American Journal of Diseases of Children. 1980 ; Vol. 134, No. 5. pp. 492-494.
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