Abstract
A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.
| Original language | English |
|---|---|
| Pages (from-to) | 492-494 |
| Number of pages | 3 |
| Journal | American Journal of Diseases of Children |
| Volume | 134 |
| Issue number | 5 |
| State | Published - Aug 22 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia. / Stoerner, J. W.; Butler, I. J.; Morriss, F. H.; Howell, R.; Seifert, W. E.; Caprioli, R. M.; Adcock IIIrd, E. W.; Denson, S. E.
In: American Journal of Diseases of Children, Vol. 134, No. 5, 22.08.1980, p. 492-494.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia
AU - Stoerner, J. W.
AU - Butler, I. J.
AU - Morriss, F. H.
AU - Howell, R.
AU - Seifert, W. E.
AU - Caprioli, R. M.
AU - Adcock IIIrd, E. W.
AU - Denson, S. E.
PY - 1980/8/22
Y1 - 1980/8/22
N2 - A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.
AB - A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018868667&partnerID=8YFLogxK
M3 - Article
C2 - 6155067
AN - SCOPUS:0018868667
VL - 134
SP - 492
EP - 494
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 5
ER -