CSF Neurotransmitter Studies: An Infant With Ascorbic Acid-Responsive Tyrosinemia

Joan W. Stoerner; Ian J. Butler; Frank H. Morriss; R. Rodney Howell; William E. Seifert; Richard M. Caprioli; Eugene W. Adcock; Susan E. Denson

doi:10.1001/archpedi.1980.02130170042014

CSF Neurotransmitter Studies: An Infant With Ascorbic Acid-Responsive Tyrosinemia

Joan W. Stoerner, Ian J. Butler, Frank H. Morriss, R. Rodney Howell, William E. Seifert, Richard M. Caprioli, Eugene W. Adcock, Susan E. Denson

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.

Original language	English (US)
Pages (from-to)	492-494
Number of pages	3
Journal	American Journal of Diseases of Children
Volume	134
Issue number	5
DOIs	https://doi.org/10.1001/archpedi.1980.02130170042014
State	Published - May 1980
Externally published	Yes

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ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

Stoerner, J. W., Butler, I. J., Morriss, F. H., Howell, R. R., Seifert, W. E., Caprioli, R. M., Adcock, E. W., & Denson, S. E. (1980). CSF Neurotransmitter Studies: An Infant With Ascorbic Acid-Responsive Tyrosinemia. American Journal of Diseases of Children, 134(5), 492-494. https://doi.org/10.1001/archpedi.1980.02130170042014

CSF Neurotransmitter Studies : An Infant With Ascorbic Acid-Responsive Tyrosinemia. / Stoerner, Joan W.; Butler, Ian J.; Morriss, Frank H.; Howell, R. Rodney; Seifert, William E.; Caprioli, Richard M.; Adcock, Eugene W.; Denson, Susan E.

In: American Journal of Diseases of Children, Vol. 134, No. 5, 05.1980, p. 492-494.

Research output: Contribution to journal › Article

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Access to Document

10.1001/archpedi.1980.02130170042014