CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorder

Rajiv P. Sharma, Philip G. Janicak, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journalArticle

85 Scopus citations


Objective: The relationship between CSF neurotensin concentrations and measures of psychopathology in patients with schizophrenia or schizoaffective disorder was examined before and after treatment with antipsychotic drugs. Method: CSF neurotensin concentrations were measured in 42 drug-free patients with schizophrenia or schizoaffective disorder. For 18 of these patients, CSF neurotensin was measured again after 4 weeks of antipsychotic treatment. Results: Significantly higher levels of pretreatment psychopathology were observed in the patients with the lowest CSF neurotensin concentrations. Furthermore, improvements in overall psychopathology and, particularly, negative symptoms were correlated with increases in CSF neurotensin concentrations during treatment. Conclusions: These findings provide further evidence for a role of neurotensin in the pathophysiology of psychosis and in the mechanism of action of antipsychotic drugs.

Original languageEnglish (US)
Pages (from-to)1019-1021
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number7
StatePublished - Jul 1997


ASJC Scopus subject areas

  • Psychiatry and Mental health

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