CSF monoamine metabolites in chronic pain

Randal D. France, Bruno J. Urban, Susan Pelton, Clinton D. Kilts, Jau Shyong Hong, Charles Nemeroff

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Metabolites of selected neurotransmitters (5-HIAA, HVA and DOPAC) and beta-endorphin were measured in the CSF of 39 chronic pain patients and compared to controls. Twelve of the pain patients also fulfilled criteria for major depression. The concentration of 5-HIAA was increased in female but not male pain patients; there was no significant difference in the CSF concentrations of HVA and DOPAC. The presence of depression did not influence the concentrations of neurotransmitters. No correlation was found between the concentrations of monoamine metabolites and beta-endorphin. However, there was a positive correlation between 5-HIAA and HVA in controls and chronic pain patients without depression but not in depressed patients. It is concluded: chronic pain states are associated with elevation of CSF 5-HIAA in female patients; depression abolishes a positive correlation between 5-HIAA and HVA.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalPain
Volume31
Issue number2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Hydroxyindoleacetic Acid
Chronic Pain
Depression
3,4-Dihydroxyphenylacetic Acid
beta-Endorphin
Neurotransmitter Agents
Pain

Keywords

  • Chronic pain states
  • CSF
  • Depression
  • Neurotransmitters

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

France, R. D., Urban, B. J., Pelton, S., Kilts, C. D., Hong, J. S., & Nemeroff, C. (1987). CSF monoamine metabolites in chronic pain. Pain, 31(2), 189-198. https://doi.org/10.1016/0304-3959(87)90035-2

CSF monoamine metabolites in chronic pain. / France, Randal D.; Urban, Bruno J.; Pelton, Susan; Kilts, Clinton D.; Hong, Jau Shyong; Nemeroff, Charles.

In: Pain, Vol. 31, No. 2, 01.01.1987, p. 189-198.

Research output: Contribution to journalArticle

France, RD, Urban, BJ, Pelton, S, Kilts, CD, Hong, JS & Nemeroff, C 1987, 'CSF monoamine metabolites in chronic pain', Pain, vol. 31, no. 2, pp. 189-198. https://doi.org/10.1016/0304-3959(87)90035-2
France RD, Urban BJ, Pelton S, Kilts CD, Hong JS, Nemeroff C. CSF monoamine metabolites in chronic pain. Pain. 1987 Jan 1;31(2):189-198. https://doi.org/10.1016/0304-3959(87)90035-2
France, Randal D. ; Urban, Bruno J. ; Pelton, Susan ; Kilts, Clinton D. ; Hong, Jau Shyong ; Nemeroff, Charles. / CSF monoamine metabolites in chronic pain. In: Pain. 1987 ; Vol. 31, No. 2. pp. 189-198.
@article{fdfa04ff0dfb42f2b4de8c5427a872ba,
title = "CSF monoamine metabolites in chronic pain",
abstract = "Metabolites of selected neurotransmitters (5-HIAA, HVA and DOPAC) and beta-endorphin were measured in the CSF of 39 chronic pain patients and compared to controls. Twelve of the pain patients also fulfilled criteria for major depression. The concentration of 5-HIAA was increased in female but not male pain patients; there was no significant difference in the CSF concentrations of HVA and DOPAC. The presence of depression did not influence the concentrations of neurotransmitters. No correlation was found between the concentrations of monoamine metabolites and beta-endorphin. However, there was a positive correlation between 5-HIAA and HVA in controls and chronic pain patients without depression but not in depressed patients. It is concluded: chronic pain states are associated with elevation of CSF 5-HIAA in female patients; depression abolishes a positive correlation between 5-HIAA and HVA.",
keywords = "Chronic pain states, CSF, Depression, Neurotransmitters",
author = "France, {Randal D.} and Urban, {Bruno J.} and Susan Pelton and Kilts, {Clinton D.} and Hong, {Jau Shyong} and Charles Nemeroff",
year = "1987",
month = "1",
day = "1",
doi = "10.1016/0304-3959(87)90035-2",
language = "English",
volume = "31",
pages = "189--198",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - CSF monoamine metabolites in chronic pain

AU - France, Randal D.

AU - Urban, Bruno J.

AU - Pelton, Susan

AU - Kilts, Clinton D.

AU - Hong, Jau Shyong

AU - Nemeroff, Charles

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Metabolites of selected neurotransmitters (5-HIAA, HVA and DOPAC) and beta-endorphin were measured in the CSF of 39 chronic pain patients and compared to controls. Twelve of the pain patients also fulfilled criteria for major depression. The concentration of 5-HIAA was increased in female but not male pain patients; there was no significant difference in the CSF concentrations of HVA and DOPAC. The presence of depression did not influence the concentrations of neurotransmitters. No correlation was found between the concentrations of monoamine metabolites and beta-endorphin. However, there was a positive correlation between 5-HIAA and HVA in controls and chronic pain patients without depression but not in depressed patients. It is concluded: chronic pain states are associated with elevation of CSF 5-HIAA in female patients; depression abolishes a positive correlation between 5-HIAA and HVA.

AB - Metabolites of selected neurotransmitters (5-HIAA, HVA and DOPAC) and beta-endorphin were measured in the CSF of 39 chronic pain patients and compared to controls. Twelve of the pain patients also fulfilled criteria for major depression. The concentration of 5-HIAA was increased in female but not male pain patients; there was no significant difference in the CSF concentrations of HVA and DOPAC. The presence of depression did not influence the concentrations of neurotransmitters. No correlation was found between the concentrations of monoamine metabolites and beta-endorphin. However, there was a positive correlation between 5-HIAA and HVA in controls and chronic pain patients without depression but not in depressed patients. It is concluded: chronic pain states are associated with elevation of CSF 5-HIAA in female patients; depression abolishes a positive correlation between 5-HIAA and HVA.

KW - Chronic pain states

KW - CSF

KW - Depression

KW - Neurotransmitters

UR - http://www.scopus.com/inward/record.url?scp=0023638425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023638425&partnerID=8YFLogxK

U2 - 10.1016/0304-3959(87)90035-2

DO - 10.1016/0304-3959(87)90035-2

M3 - Article

C2 - 2448727

AN - SCOPUS:0023638425

VL - 31

SP - 189

EP - 198

JO - Pain

JF - Pain

SN - 0304-3959

IS - 2

ER -