CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia

C. M. Banki, G. Bissette, M. Arato, L. O'Connor, C. B. Nemeroff

Research output: Contribution to journalArticlepeer-review

307 Scopus citations


To further investigate the hypothesis that hyperactivity of the hypothalamic-pituitary-adrenal axis in patients with depression may be mediated by hypersecretion of corticotropin-releasing factor (CRF), the authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic and four manic) subjects. The CSF CRF concentration was markedly higher (almost twofold) in depressed patients than in control subjects and nondepressed psychiatric patients. The concentration of CSF CRF was slightly but significantly higher in schizophrenic patients than in control subjects. These findings provide further support for the hypothesis that CRF hypersecretion occurs in major depression.

Original languageEnglish (US)
Pages (from-to)873-877
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number7
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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