CSF corticotropin-releasing factor (CRF) in Alzheimer's disease: Its relationship to severity of dementia and monoamine metabolites

Nunzio Pomara, Rajkumar R. Singh, Dennis Deptula, Peter A. LeWitt, Garth Bissette, Michael Stanley, Charles B. Nemeroff

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalBiological Psychiatry
Volume26
Issue number5
DOIs
StatePublished - Sep 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

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