CSF corticotropin-releasing factor (CRF) in Alzheimer's disease: Its relationship to severity of dementia and monoamine metabolites

Nunzio Pomara, Rajkumar R. Singh, Dennis Deptula, Peter A. LeWitt, Garth Bissette, Michael Stanley, Charles Nemeroff

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.

Original languageEnglish
Pages (from-to)500-504
Number of pages5
JournalBiological Psychiatry
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Corticotropin-Releasing Hormone
Cerebrospinal Fluid
Dementia
Alzheimer Disease
Hydroxyindoleacetic Acid
Homovanillic Acid
Neurons

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

CSF corticotropin-releasing factor (CRF) in Alzheimer's disease : Its relationship to severity of dementia and monoamine metabolites. / Pomara, Nunzio; Singh, Rajkumar R.; Deptula, Dennis; LeWitt, Peter A.; Bissette, Garth; Stanley, Michael; Nemeroff, Charles.

In: Biological Psychiatry, Vol. 26, No. 5, 01.01.1989, p. 500-504.

Research output: Contribution to journalArticle

Pomara, Nunzio ; Singh, Rajkumar R. ; Deptula, Dennis ; LeWitt, Peter A. ; Bissette, Garth ; Stanley, Michael ; Nemeroff, Charles. / CSF corticotropin-releasing factor (CRF) in Alzheimer's disease : Its relationship to severity of dementia and monoamine metabolites. In: Biological Psychiatry. 1989 ; Vol. 26, No. 5. pp. 500-504.
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