Abstract
The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 500-504 |
| Number of pages | 5 |
| Journal | Biological Psychiatry |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biological Psychiatry
Cite this
CSF corticotropin-releasing factor (CRF) in Alzheimer's disease : Its relationship to severity of dementia and monoamine metabolites. / Pomara, Nunzio; Singh, Rajkumar R.; Deptula, Dennis; LeWitt, Peter A.; Bissette, Garth; Stanley, Michael; Nemeroff, Charles.
In: Biological Psychiatry, Vol. 26, No. 5, 01.01.1989, p. 500-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CSF corticotropin-releasing factor (CRF) in Alzheimer's disease
T2 - Its relationship to severity of dementia and monoamine metabolites
AU - Pomara, Nunzio
AU - Singh, Rajkumar R.
AU - Deptula, Dennis
AU - LeWitt, Peter A.
AU - Bissette, Garth
AU - Stanley, Michael
AU - Nemeroff, Charles
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.
AB - The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.
UR - http://www.scopus.com/inward/record.url?scp=0024399769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024399769&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(89)90071-1
DO - 10.1016/0006-3223(89)90071-1
M3 - Article
C2 - 2477071
AN - SCOPUS:0024399769
VL - 26
SP - 500
EP - 504
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 5
ER -