Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: A prospective multicenter study

Somnuek Sungkanuparph, Scott G. Filler, Ploenchan Chetchotisakd, Peter G. Pappas, Tracy L. Nolen, Weerawat Manosuthi, Thanomsak Anekthananon, Michèle I. Morris, Khuanchai Supparatpinyo, Heather Kopetskie, Amy S. Kendrick, Philip C. Johnson, Jack D. Sobel, Robert A. Larsen

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.

Original languageEnglish (US)
Pages (from-to)931-934
Number of pages4
JournalClinical Infectious Diseases
Volume49
Issue number6
DOIs
StatePublished - Sep 15 2009

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Sungkanuparph, S., Filler, S. G., Chetchotisakd, P., Pappas, P. G., Nolen, T. L., Manosuthi, W., Anekthananon, T., Morris, M. I., Supparatpinyo, K., Kopetskie, H., Kendrick, A. S., Johnson, P. C., Sobel, J. D., & Larsen, R. A. (2009). Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: A prospective multicenter study. Clinical Infectious Diseases, 49(6), 931-934. https://doi.org/10.1086/605497