Crowded charge in biological ion channels

D. Gillespie, W. Nonner, R. S. Eisenberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

Biological ion channels are proteins that conduct ions across lipid membranes that are otherwise impermeable to them. Modern theories of electrolyte solutions that include the finite size of the ions has been shown to be a very successful method for modeling ion channels and we continue that work here. We consider a model of ion flux through a calcium-selective ion channel and calculate the components of the chemical potential using density functional theory of electrolyte solutions. For different bath ion concentrations of K + and Ca 2+ current/voltage curves are computed and the three components of the chemical potentials of the ions are examined.

Original languageEnglish (US)
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages435-438
Number of pages4
StatePublished - Dec 1 2003
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Publication series

Name2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume3

Other

Other2003 Nanotechnology Conference and Trade Show - Nanotech 2003
CountryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Keywords

  • Density functional theory
  • Ion channels

ASJC Scopus subject areas

  • Engineering(all)

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