Crowded charge in biological ion channels

D. Gillespie, W. Nonner, R. S. Eisenberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Biological ion channels are proteins that conduct ions across lipid membranes that are otherwise impermeable to them. Modern theories of electrolyte solutions that include the finite size of the ions has been shown to be a very successful method for modeling ion channels and we continue that work here. We consider a model of ion flux through a calcium-selective ion channel and calculate the components of the chemical potential using density functional theory of electrolyte solutions. For different bath ion concentrations of K + and Ca 2+ current/voltage curves are computed and the three components of the chemical potentials of the ions are examined.

Original languageEnglish
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages435-438
Number of pages4
Volume3
StatePublished - Dec 1 2003
Externally publishedYes
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Other

Other2003 Nanotechnology Conference and Trade Show - Nanotech 2003
CountryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Fingerprint

Ions
Chemical potential
Electrolytes
Density functional theory
Calcium
Fluxes
Proteins
Electric potential

Keywords

  • Density functional theory
  • Ion channels

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Gillespie, D., Nonner, W., & Eisenberg, R. S. (2003). Crowded charge in biological ion channels. In M. Laudon, & B. Romanowicz (Eds.), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 (Vol. 3, pp. 435-438)

Crowded charge in biological ion channels. / Gillespie, D.; Nonner, W.; Eisenberg, R. S.

2003 Nanotechnology Conference and Trade Show - Nanotech 2003. ed. / M. Laudon; B. Romanowicz. Vol. 3 2003. p. 435-438.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gillespie, D, Nonner, W & Eisenberg, RS 2003, Crowded charge in biological ion channels. in M Laudon & B Romanowicz (eds), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003. vol. 3, pp. 435-438, 2003 Nanotechnology Conference and Trade Show - Nanotech 2003, San Francisco, CA, United States, 2/23/03.
Gillespie D, Nonner W, Eisenberg RS. Crowded charge in biological ion channels. In Laudon M, Romanowicz B, editors, 2003 Nanotechnology Conference and Trade Show - Nanotech 2003. Vol. 3. 2003. p. 435-438
Gillespie, D. ; Nonner, W. ; Eisenberg, R. S. / Crowded charge in biological ion channels. 2003 Nanotechnology Conference and Trade Show - Nanotech 2003. editor / M. Laudon ; B. Romanowicz. Vol. 3 2003. pp. 435-438
@inproceedings{83a694dc78254a869d69050c96ac4833,
title = "Crowded charge in biological ion channels",
abstract = "Biological ion channels are proteins that conduct ions across lipid membranes that are otherwise impermeable to them. Modern theories of electrolyte solutions that include the finite size of the ions has been shown to be a very successful method for modeling ion channels and we continue that work here. We consider a model of ion flux through a calcium-selective ion channel and calculate the components of the chemical potential using density functional theory of electrolyte solutions. For different bath ion concentrations of K + and Ca 2+ current/voltage curves are computed and the three components of the chemical potentials of the ions are examined.",
keywords = "Density functional theory, Ion channels",
author = "D. Gillespie and W. Nonner and Eisenberg, {R. S.}",
year = "2003",
month = "12",
day = "1",
language = "English",
isbn = "0972842209",
volume = "3",
pages = "435--438",
editor = "M. Laudon and B. Romanowicz",
booktitle = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",

}

TY - GEN

T1 - Crowded charge in biological ion channels

AU - Gillespie, D.

AU - Nonner, W.

AU - Eisenberg, R. S.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Biological ion channels are proteins that conduct ions across lipid membranes that are otherwise impermeable to them. Modern theories of electrolyte solutions that include the finite size of the ions has been shown to be a very successful method for modeling ion channels and we continue that work here. We consider a model of ion flux through a calcium-selective ion channel and calculate the components of the chemical potential using density functional theory of electrolyte solutions. For different bath ion concentrations of K + and Ca 2+ current/voltage curves are computed and the three components of the chemical potentials of the ions are examined.

AB - Biological ion channels are proteins that conduct ions across lipid membranes that are otherwise impermeable to them. Modern theories of electrolyte solutions that include the finite size of the ions has been shown to be a very successful method for modeling ion channels and we continue that work here. We consider a model of ion flux through a calcium-selective ion channel and calculate the components of the chemical potential using density functional theory of electrolyte solutions. For different bath ion concentrations of K + and Ca 2+ current/voltage curves are computed and the three components of the chemical potentials of the ions are examined.

KW - Density functional theory

KW - Ion channels

UR - http://www.scopus.com/inward/record.url?scp=6344249153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6344249153&partnerID=8YFLogxK

M3 - Conference contribution

SN - 0972842209

SN - 9780972842204

VL - 3

SP - 435

EP - 438

BT - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

A2 - Laudon, M.

A2 - Romanowicz, B.

ER -