Cross-reactivity among the products of three nonallelic H-2 loci, H-2L(d), H-2D(q), and H-2K(k)

T. H. Hansen, P. Ivanyi, Robert B Levy, D. H. Sachs

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cross-reactions of the products of three nonallelic H-2 loci, H-2K, H-2D, and H-2L, have been studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between L(d) and D(d) molecules but absent on D(d) molecules. By cytotoxic screening of sera from individual mice an exceptional anti-L(d) serum was found which cross-reacted with an H-2(k) antigen. Genetic mapping studies suggested that the basis of this activity was an L(d)-K(k) serological cross-reaction. Cytotoxic T cells generated to L(d) alloantigens were also found to recognize a cross-reacting K(k) determinant. These studies therefore suggest that L, D, and K are three structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.

Original languageEnglish
Pages (from-to)339-342
Number of pages4
JournalTransplantation
Volume28
Issue number4
StatePublished - Dec 1 1979
Externally publishedYes

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Histocompatibility Antigen H-2D
Cross Reactions
H-2 Antigens
Isoantigens
Membrane Glycoproteins
Serum
Immunoprecipitation
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Cross-reactivity among the products of three nonallelic H-2 loci, H-2L(d), H-2D(q), and H-2K(k). / Hansen, T. H.; Ivanyi, P.; Levy, Robert B; Sachs, D. H.

In: Transplantation, Vol. 28, No. 4, 01.12.1979, p. 339-342.

Research output: Contribution to journalArticle

Hansen, T. H. ; Ivanyi, P. ; Levy, Robert B ; Sachs, D. H. / Cross-reactivity among the products of three nonallelic H-2 loci, H-2L(d), H-2D(q), and H-2K(k). In: Transplantation. 1979 ; Vol. 28, No. 4. pp. 339-342.
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