Cross-reactivity among the products of three nonallelic H-2 loci, H-2Ld, H-2Dq, and H-2Kk

T. H. Hansen, P. Ivanyi, R. B. Levy, D. H. Sachs

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Cross-reactions of the products of three nonallelic H-2 loci, H-2K, H-2D, and H-2L, have been studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between L(d) and D(d) molecules but absent on D(d) molecules. By cytotoxic screening of sera from individual mice an exceptional anti-L(d) serum was found which cross-reacted with an H-2(k) antigen. Genetic mapping studies suggested that the basis of this activity was an L(d)-K(k) serological cross-reaction. Cytotoxic T cells generated to L(d) alloantigens were also found to recognize a cross-reacting K(k) determinant. These studies therefore suggest that L, D, and K are three structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
Issue number4
StatePublished - Oct 1979
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation


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