Abstract
Cross-reactions of the products of three nonallelic H-2 loci, H-2K, H-2D, and H-2L, have been studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between L(d) and D(d) molecules but absent on D(d) molecules. By cytotoxic screening of sera from individual mice an exceptional anti-L(d) serum was found which cross-reacted with an H-2(k) antigen. Genetic mapping studies suggested that the basis of this activity was an L(d)-K(k) serological cross-reaction. Cytotoxic T cells generated to L(d) alloantigens were also found to recognize a cross-reacting K(k) determinant. These studies therefore suggest that L, D, and K are three structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.
| Original language | English |
|---|---|
| Pages (from-to) | 339-342 |
| Number of pages | 4 |
| Journal | Transplantation |
| Volume | 28 |
| Issue number | 4 |
| State | Published - Dec 1 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Transplantation
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Cross-reactivity among the products of three nonallelic H-2 loci, H-2L(d), H-2D(q), and H-2K(k). / Hansen, T. H.; Ivanyi, P.; Levy, Robert B; Sachs, D. H.
In: Transplantation, Vol. 28, No. 4, 01.12.1979, p. 339-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cross-reactivity among the products of three nonallelic H-2 loci, H-2L(d), H-2D(q), and H-2K(k)
AU - Hansen, T. H.
AU - Ivanyi, P.
AU - Levy, Robert B
AU - Sachs, D. H.
PY - 1979/12/1
Y1 - 1979/12/1
N2 - Cross-reactions of the products of three nonallelic H-2 loci, H-2K, H-2D, and H-2L, have been studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between L(d) and D(d) molecules but absent on D(d) molecules. By cytotoxic screening of sera from individual mice an exceptional anti-L(d) serum was found which cross-reacted with an H-2(k) antigen. Genetic mapping studies suggested that the basis of this activity was an L(d)-K(k) serological cross-reaction. Cytotoxic T cells generated to L(d) alloantigens were also found to recognize a cross-reacting K(k) determinant. These studies therefore suggest that L, D, and K are three structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.
AB - Cross-reactions of the products of three nonallelic H-2 loci, H-2K, H-2D, and H-2L, have been studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between L(d) and D(d) molecules but absent on D(d) molecules. By cytotoxic screening of sera from individual mice an exceptional anti-L(d) serum was found which cross-reacted with an H-2(k) antigen. Genetic mapping studies suggested that the basis of this activity was an L(d)-K(k) serological cross-reaction. Cytotoxic T cells generated to L(d) alloantigens were also found to recognize a cross-reacting K(k) determinant. These studies therefore suggest that L, D, and K are three structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.
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M3 - Article
C2 - 505544
AN - SCOPUS:0018675021
VL - 28
SP - 339
EP - 342
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 4
ER -