CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects

L. McLoughlin, S. Tomlin, A. Grossman, N. Lytras, Andrew V Schally, D. Coy, G. M. Besser, L. H. Rees

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A prompt rise in circulating immunoreactive N- and C-terminal lipotrophin (LPH) accompanied the increase on ACTH when 100 μg CRF-412 was given to 6 normal male subjects. Chromatography of the basal and peak 15-min values showed that there was an equimolar increase in β-LPH and β-endorphin, to cause parallel release of ACTH, β-endorphin and β-LPH from the pro-opiocortin precursor.

Original languageEnglish
Pages (from-to)282-284
Number of pages3
JournalNeuroendocrinology
Volume38
Issue number4
StatePublished - May 17 1984
Externally publishedYes

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Endorphins
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Pro-Opiomelanocortin
Chromatography

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

McLoughlin, L., Tomlin, S., Grossman, A., Lytras, N., Schally, A. V., Coy, D., ... Rees, L. H. (1984). CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects. Neuroendocrinology, 38(4), 282-284.

CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects. / McLoughlin, L.; Tomlin, S.; Grossman, A.; Lytras, N.; Schally, Andrew V; Coy, D.; Besser, G. M.; Rees, L. H.

In: Neuroendocrinology, Vol. 38, No. 4, 17.05.1984, p. 282-284.

Research output: Contribution to journalArticle

McLoughlin, L, Tomlin, S, Grossman, A, Lytras, N, Schally, AV, Coy, D, Besser, GM & Rees, LH 1984, 'CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects', Neuroendocrinology, vol. 38, no. 4, pp. 282-284.
McLoughlin L, Tomlin S, Grossman A, Lytras N, Schally AV, Coy D et al. CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects. Neuroendocrinology. 1984 May 17;38(4):282-284.
McLoughlin, L. ; Tomlin, S. ; Grossman, A. ; Lytras, N. ; Schally, Andrew V ; Coy, D. ; Besser, G. M. ; Rees, L. H. / CRF-41 stimulates the release of β-lipotrophin and β-endorphin in normal human subjects. In: Neuroendocrinology. 1984 ; Vol. 38, No. 4. pp. 282-284.
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