CRF-41 Stimulates the Release of β-Lipotrophin and β-Endorphin in Normal Human Subjects

Lorraine McLaughlin, Susan Tomlin, A. Grossman, N. Lytras, A. V. Schally, D. Coy, Gordon M. Besser, Lesley H. Rees

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A prompt rise in circulating immunoreactive N- and C-terminal lipotrophin (LPH) accompanied the increase on ACTH when 100 μg CRF-412 was given to 6 normal male subjects. Chromatography of the basal and peak 15-min values showed that there was an equimolar increase in β-LPH and β-endorphin, to cause parallel release of ACTH, β-endorphin and β-LPH from the pro-opiocortin precursor.

Original languageEnglish (US)
Pages (from-to)282-284
Number of pages3
JournalNeuroendocrinology
Volume38
Issue number4
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Keywords

  • Corticotrophin-releasing factor
  • Normal subjects
  • ß-Endorphin
  • ß-Lipotrophin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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