Craniopharyngiomas. A clinical and pathological review

Carol K. Petito, Umberto Degirolami, Kenneth M. Earle

Research output: Contribution to journalArticlepeer-review

206 Scopus citations


From the files of the AFIP 245 cases were reviewed statistically with reference to their gross and microscopic appearance and clinical data. The majority of the tumors were cystic and microscopically, cysts were formed by squamous epithelial maturation, by degeneration of the stellate cells at the centers of adamantinomatous nests, or by degeneration of the stroma. Transitional forms were seen between adamantinomatous and squamous epithelium, while keratohyaline granules and keratin were present in some cases. Because of this overlap, differentiation between craniopharyngiomas and suprasellar epidermoid cysts often is not possible. Significantly increased actuarial survival rates were associated with absence of calcification in plain skull films in adults, negative CSF examination, and tumor size under 3.0 cm.

Original languageEnglish (US)
Pages (from-to)1944-1952
Number of pages9
Issue number4
StatePublished - Apr 1976
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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