Crack cocaine: Effect modifier of RNA viral load and CD4 count in hiv infected african american women

Robert Duncan, Paul Shapshak, John Page, Francesco Chiappelli, Clyde B McCoy, Sarah Messiah

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This study reports on the role of cocaine as effect modifier of the association of CD4+ cell counts and RNA viral load. HIV-1 seropositive (n = 80) and seronegative (n= 42) African American women (AAW) crack cocaine smokers were recruited. Increasing cocaine use, based on self-reports and laboratory values, significantly exacerbates the immunopathology of HIV-1 in a dose-response manner, confirmed by a non-linear drop in CD4+ cell number for a given viral load in HIV+ AAW. This report supports a view of deleterious effects due to cocaine use in humans.

Original languageEnglish
Pages (from-to)1488-1495
Number of pages8
JournalFrontiers in Bioscience
Volume12
Issue number4
DOIs
StatePublished - Jun 6 2007

Fingerprint

Crack Cocaine
Viral RNA
CD4 Lymphocyte Count
Viral Load
Cocaine
African Americans
RNA
HIV-1
Self Report
Cell Count
HIV

Keywords

  • African American
  • CD4
  • Cocaine
  • Effect modifier
  • HIV
  • RNA viral load
  • Women

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Crack cocaine : Effect modifier of RNA viral load and CD4 count in hiv infected african american women. / Duncan, Robert; Shapshak, Paul; Page, John; Chiappelli, Francesco; McCoy, Clyde B; Messiah, Sarah.

In: Frontiers in Bioscience, Vol. 12, No. 4, 06.06.2007, p. 1488-1495.

Research output: Contribution to journalArticle

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