Crack cocaine: Effect modifier of RNA viral load and CD4 count in hiv infected african american women

Robert C. Duncan, Paul Shapshak, J. Bryan Page, Francesco Chiappelli, Clyde B. McCoy, Sarah E. Messiah

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

This study reports on the role of cocaine as effect modifier of the association of CD4+ cell counts and RNA viral load. HIV-1 seropositive (n = 80) and seronegative (n= 42) African American women (AAW) crack cocaine smokers were recruited. Increasing cocaine use, based on self-reports and laboratory values, significantly exacerbates the immunopathology of HIV-1 in a dose-response manner, confirmed by a non-linear drop in CD4+ cell number for a given viral load in HIV+ AAW. This report supports a view of deleterious effects due to cocaine use in humans.

Original languageEnglish (US)
Pages (from-to)1488-1495
Number of pages8
JournalFrontiers in Bioscience
Volume12
Issue number4
DOIs
StatePublished - Jun 6 2007

Keywords

  • African American
  • CD4
  • Cocaine
  • Effect modifier
  • HIV
  • RNA viral load
  • Women

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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