Coxsackieviruses and insulitis

Letizia Galleri, Fabio Arturo Grieco, Guido Sebastiani, Isabella Spagnuolo, Francesco Vendrame, Francesco Dotta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Coxsackievirus infections are believed to be a relevant risk factor in the induction of pancreatic beta cell damage and autoimmune response in type 1 diabetes mellitus. Genomic RNA and proteins of coxsackieviruses have been detected in tissues of type 1 diabetes patients, supporting the involvement of enteroviruses in the pathogenesis of type 1 diabetes. Coxsackieviruses may infect beta cells, trigger the activation of innate immune systems, or accelerate the autoimmune process leading to the disease. Local inflammatory changes generated in pancreatic islets and the mechanisms leading to its generation and progression have been studied in animal models of type 1 diabetes and in humans. The role of coxsackieviruses in the insulitic process is discussed in this chapter, together with the ability of selected coxsackievirus serotypes to protect against type 1 diabetes.

Original languageEnglish (US)
Title of host publicationDiabetes and Viruses
PublisherSpringer New York
Pages157-166
Number of pages10
Volume9781461440512
ISBN (Electronic)9781461440512
ISBN (Print)1461440505, 9781461440505
DOIs
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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