Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons

Yong Yoon Seung, Eun Ha Young, Eun Choi Jung, Jeonghyun Ahn, Heuiran Lee, Hee Seok Kweon, Jee Young Lee, Hou Kim Dong

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Coxsackievirus is the most important cause of meningitis and encephalitis in infants; an infection is sometimes fatal or may lead to neurodevelopmental defects. Here, we show that coxsackievirus B4 (CVB4) induces an autophagy pathway for replication in rat primary neurons. Notably, calpain inhibitors reduce autophagosome formation. Conversely, the inhibition of the autophagy pathway with 3-methyladenine inhibits calpain activation. This work reveals, for the first time, that calpain is essential for the autophagy pathway and viral replication in CVB4-infected neurons.

Original languageEnglish (US)
Pages (from-to)11976-11978
Number of pages3
JournalJournal of virology
Volume82
Issue number23
DOIs
StatePublished - Dec 1 2008

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Seung, Y. Y., Young, E. H., Jung, E. C., Ahn, J., Lee, H., Kweon, H. S., Lee, J. Y., & Dong, H. K. (2008). Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons. Journal of virology, 82(23), 11976-11978. https://doi.org/10.1128/JVI.01028-08