Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance.

Abhishek Prasad, Viswanath Sankar, Aubrey T. Dyer, Eric Knott, Qing Shan Xue, Toshikazu Nishida, John R. Reynolds, Gerry Shaw, Wolfgang Streit, Justin C. Sanchez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this work, we develop an experimental testbed that couples biotic and abiotic metrics for studying, quantifying and predicting the effects of chronic electrode implantation on neural electrode performance. The rationale is based on the observation that long-term functionality is the outcome of the interactions between the dynamics of the neuronal environment and the properties of the electrode itself. By combining and analyzing the substantially richer information available in the spatiotemporal dynamics of neurons with biotic and abiotic metrics such as biochemical markers, histochemistry, SEM imaging, and electrochemistry, we seek to quantitatively improve our understanding of the functional modifications underlying the long-term responses of electrode implants. The goal is to ultimately enable the design of future reliable interfaces. In our preliminary analysis using this biotic-abiotic approach of an electrode 18 days post-implant, we observed both structural and histochemical responses related to chronic electrode implantation. These were coupled to daily functional changes in electrode performance. Interestingly, these changes were not correlated with markers of brain injury at the time of electrode explantation. Future work using this multidisciplinary approach is directed to providing a detailed perspective into long-term microelectrode performance.

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Testbeds
Electrodes
Electrochemistry
Microelectrodes
Brain Injuries
Neurons
Brain
Biomarkers
Imaging techniques
Scanning electron microscopy

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance. / Prasad, Abhishek; Sankar, Viswanath; Dyer, Aubrey T.; Knott, Eric; Xue, Qing Shan; Nishida, Toshikazu; Reynolds, John R.; Shaw, Gerry; Streit, Wolfgang; Sanchez, Justin C.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Vol. 2011, 01.12.2011, p. 3020-3023.

Research output: Contribution to journalArticle

Prasad, Abhishek ; Sankar, Viswanath ; Dyer, Aubrey T. ; Knott, Eric ; Xue, Qing Shan ; Nishida, Toshikazu ; Reynolds, John R. ; Shaw, Gerry ; Streit, Wolfgang ; Sanchez, Justin C. / Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2011 ; Vol. 2011. pp. 3020-3023.
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