Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat: Demonstration by double-label autoradiography

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased lCMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22%) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of lCBF within the barrel field.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalNeurology
Volume37
Issue number1
StatePublished - Jan 1 1987

Fingerprint

Prosencephalon
Autoradiography
Blood Glucose
Vibrissae
Blood Preservation
Wistar Rats
Carbon
Glucose

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{734d994539f84b35a412ef06a195e662,
title = "Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat: Demonstration by double-label autoradiography",
abstract = "To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased lCMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22{\%}) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of lCBF within the barrel field.",
author = "Myron Ginsberg and {Dalton Dietrich}, W. and R. Busto",
year = "1987",
month = "1",
day = "1",
language = "English",
volume = "37",
pages = "11--19",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat

T2 - Demonstration by double-label autoradiography

AU - Ginsberg, Myron

AU - Dalton Dietrich, W.

AU - Busto, R.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased lCMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22%) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of lCBF within the barrel field.

AB - To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased lCMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22%) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of lCBF within the barrel field.

UR - http://www.scopus.com/inward/record.url?scp=0023086259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023086259&partnerID=8YFLogxK

M3 - Article

C2 - 3796826

AN - SCOPUS:0023086259

VL - 37

SP - 11

EP - 19

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -