Coumaryl crown ether based chemosensors: Selective detection of saxitoxin in the presence of sodium and potassium ions

Péter Kele, Jhony Orbulescu, Tiffany L. Calhoun, Robert E. Gawley, Roger M. Leblanc

Research output: Contribution to journalArticle

51 Scopus citations


Two novel fluorescent chemosensors in which an aza-crown is linked to 4-coumaryl fluorophores by a methylene spacer have been synthesized for sensing saxitoxin. Fluorescence enhancement was observed upon binding of the dicationic toxin molecule, whereas several metal ions produced no effect.

Original languageEnglish (US)
Pages (from-to)4413-4416
Number of pages4
JournalTetrahedron Letters
Issue number25
StatePublished - Jun 17 2002



  • Coumarin
  • Fluorescence
  • Saxitoxin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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