Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice

Andrew J. McKnight, Victor L. Perez, Colleen M. Shea, Gary S. Gray, Abul K. Abbas

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


The role of costimulation in Ag-induced responses of naive and differentiated IL-2 and IL-4-producing CD4+ T cells has been examined using cells from mice expressing a transgenic TCR specific for cytochrome c (81- 104) + I-E(k). IL-2 secretion by naive and pre-activated T cells is dependent on costimulation, because it is not induced with chemically fixed APCs and is significantly inhibited by the B7 antagonist, CTLA4-Ig. In contrast, IL-4 secretion by in vitro differentiated Th2-like cells is relatively independent of costimulators. Thus, the requirement for costimulation is related more to lymphokine secretion profiles than to the previous activation status of CD4+ T lymphocytes.

Original languageEnglish (US)
Pages (from-to)5220-5225
Number of pages6
JournalJournal of Immunology
Issue number11
StatePublished - Jun 1 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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