Cost and morbidity associated with antibiotic prophylaxis in the ICU

Nicholas Namias, Sarah Harvill, Suzette Ball, Mark G. McKenney, Jeffrey P. Salomone, Joseph M. Civetta

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Although the high cost and inappropriate use of antibiotics have been documented before, we are not aware of any data on nonsurgical site infectious morbidity associated with prolonged courses of prophylactic antibiotics (PA). Study Design: Data regarding antibiotic orders were collected using a custom designed microbiology database in the Surgical Intensive Care Unit of a teaching hospital from October 1, 1995 through April 30, 1997. The database was retrospectively reviewed. The cost of PA in excess of 1 day was calculated. Frequency of bacteremia and line infections were compared in patients receiving 1 day or less of PA versus more than 4 days of PA. Results: Sixty-one percent of PA orders were continued for more than 1 day. Cost of PA beyond 1 day totaled $44,893. Bacteremia and line infection were more frequent in the patients receiving more than 4 days of PA. Conclusions: There was poor compliance with the protocol of stopping PA at 24 hours. The cost of noncompliance was $44,893. There were more bacteremias and line infections in patients with duration of PA of more than 4 days.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of the American College of Surgeons
Volume188
Issue number3
DOIs
StatePublished - Mar 1 1999

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Antibiotic Prophylaxis
Anti-Bacterial Agents
Morbidity
Costs and Cost Analysis
Bacteremia
Infection
Databases
Guideline Adherence
Critical Care
Microbiology
Teaching Hospitals
Intensive Care Units

ASJC Scopus subject areas

  • Surgery

Cite this

Cost and morbidity associated with antibiotic prophylaxis in the ICU. / Namias, Nicholas; Harvill, Sarah; Ball, Suzette; McKenney, Mark G.; Salomone, Jeffrey P.; Civetta, Joseph M.

In: Journal of the American College of Surgeons, Vol. 188, No. 3, 01.03.1999, p. 225-230.

Research output: Contribution to journalArticle

Namias, Nicholas ; Harvill, Sarah ; Ball, Suzette ; McKenney, Mark G. ; Salomone, Jeffrey P. ; Civetta, Joseph M. / Cost and morbidity associated with antibiotic prophylaxis in the ICU. In: Journal of the American College of Surgeons. 1999 ; Vol. 188, No. 3. pp. 225-230.
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