Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine

Katia P. Karalis, Effie Kontopoulos, Louis J. Muglia, Joseph A. Majzoub

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Traditionally, the adrenal gland has been considered an important endocrine component of the pathway to inhibit acute inflammation via hypothalamic corticotropin-releasing hormone (CRH)-mediated secretion of glucocorticoid. Immunoreactive CRH found in inflamed tissues is a potent proinflammatory factor. Using genetic and pharmacological models of CRH deficiency, we now show that CRH deficiency unmasks a major proinflammatory effect of epinephrine secreted from the adrenal medulla. Together, epinephrine and peripheral CRH stimulate inflammation, and glucocorticoid acts as a counterbalancing force in this regard. Our findings suggest thai stimulation of the acute inflammatory response should be included with the other 'fight-or-flight' actions of epinephrine.

Original languageEnglish (US)
Pages (from-to)7093-7097
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number12
DOIs
StatePublished - Jun 8 1999

ASJC Scopus subject areas

  • General

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