Abstract
Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.
| Original language | English |
|---|---|
| Pages (from-to) | 355-359 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 437 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 29 1987 |
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Keywords
- Basal ganglia
- Corticotropin-releasing hormone
- Huntington's disease
- Postmortem human brain
- Radioimmunoassay
- Somatostatin
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease. / De Souza, Errol B.; Whitehouse, Peter J.; Folstein, Susan E.; Price, Donald L.; Vale, Wylie W.
In: Brain Research, Vol. 437, No. 2, 29.12.1987, p. 355-359.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease
AU - De Souza, Errol B.
AU - Whitehouse, Peter J.
AU - Folstein, Susan E.
AU - Price, Donald L.
AU - Vale, Wylie W.
PY - 1987/12/29
Y1 - 1987/12/29
N2 - Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.
AB - Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.
KW - Basal ganglia
KW - Corticotropin-releasing hormone
KW - Huntington's disease
KW - Postmortem human brain
KW - Radioimmunoassay
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0023567411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023567411&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(87)91651-9
DO - 10.1016/0006-8993(87)91651-9
M3 - Article
C2 - 2893655
AN - SCOPUS:0023567411
VL - 437
SP - 355
EP - 359
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -