Abstract
Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.
Original language | English (US) |
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Pages (from-to) | 355-359 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 437 |
Issue number | 2 |
DOIs | |
State | Published - Dec 29 1987 |
Keywords
- Basal ganglia
- Corticotropin-releasing hormone
- Huntington's disease
- Postmortem human brain
- Radioimmunoassay
- Somatostatin
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)