Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease

Errol B. De Souza, Peter J. Whitehouse, Susan E. Folstein, Donald L. Price, Wylie W. Vale

Research output: Contribution to journalArticle

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Abstract

Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalBrain Research
Volume437
Issue number2
DOIs
StatePublished - Dec 29 1987

Fingerprint

Corticotropin-Releasing Hormone
Huntington Disease
Basal Ganglia
Putamen
Progressive Supranuclear Palsy
Occipital Lobe
Parietal Lobe
Globus Pallidus
Gyrus Cinguli
Frontal Lobe
Temporal Lobe
Cerebral Cortex
Parkinson Disease
Alzheimer Disease
Control Groups
Brain

Keywords

  • Basal ganglia
  • Corticotropin-releasing hormone
  • Huntington's disease
  • Postmortem human brain
  • Radioimmunoassay
  • Somatostatin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

De Souza, E. B., Whitehouse, P. J., Folstein, S. E., Price, D. L., & Vale, W. W. (1987). Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease. Brain Research, 437(2), 355-359. https://doi.org/10.1016/0006-8993(87)91651-9

Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease. / De Souza, Errol B.; Whitehouse, Peter J.; Folstein, Susan E.; Price, Donald L.; Vale, Wylie W.

In: Brain Research, Vol. 437, No. 2, 29.12.1987, p. 355-359.

Research output: Contribution to journalArticle

De Souza, EB, Whitehouse, PJ, Folstein, SE, Price, DL & Vale, WW 1987, 'Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease', Brain Research, vol. 437, no. 2, pp. 355-359. https://doi.org/10.1016/0006-8993(87)91651-9
De Souza, Errol B. ; Whitehouse, Peter J. ; Folstein, Susan E. ; Price, Donald L. ; Vale, Wylie W. / Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease. In: Brain Research. 1987 ; Vol. 437, No. 2. pp. 355-359.
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