@article{74d688e48df94627bb54e9f434556db6,
title = "Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease",
abstract = "Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.",
keywords = "Basal ganglia, Corticotropin-releasing hormone, Huntington's disease, Postmortem human brain, Radioimmunoassay, Somatostatin",
author = "{De Souza}, {Errol B.} and Whitehouse, {Peter J.} and Folstein, {Susan E.} and Price, {Donald L.} and Vale, {Wylie W.}",
note = "Funding Information: 15080, NS 15721, NS 16375, NS 20471 and NS 07179, grants from the McKnight and Sloan Foundations, \]~*obert L. and Clara G. Patterson Trust and Ciaster Family funds. Research of the Clayton Foundation Laboratories for Peptide Biology was supported in 1 Aronin, N., Cooper, P.E., Lorenz, L.J., Bird, E.D., Sagar, S.M., Leeman, S.E. and Martin, J.B., Somatostatin is in-creased in the basal ganglia in Huntington's disease, Ann. Neurol., 13 (1983) 519-526. 2 Battaglia, G., Webster. E.L. and De Souza, E.B., Charac-terization of corticotropin-releasing factor (CRF) receptor-mediated adenylate cyclase activity in rat central nervous system, Synapse, in press. 3 Bird, E.D. and Iverson, L.L., Huntington's chorea: post-mortem measurement of glutamic acid decarboxylase, cho-line acetyltransferase and dopamine in basal ganglia, Brain, 97 (1974) 457-472. 4 Bissette, G., Reynolds, G.P., Kilts, C.D., Widerlov, E. and Nemeroff, C.B., Corticotropin-releasing factor-like immunoreactivity in senile dementia of the Alzheimer type, JAMA, (1985) 3067-3069. 5 Britton, D.R., Koob, G.F., Rivier, J. and Vale, W., Intra-ventricular corticotropin-releasing factor enhance~, behav-ioral effects of novelty, Life Sci., 31 (1982) 363-367. 6 Bruyn, G., Neuropathological changes in Huntington's chorea, in A. Barbeau, T.N. Chase and G.W. Paulson (Eds.), Huntington's Chorea 1872-1972, Raven, New York. 1973, pp. 399-403. 7 Bruyn, G.W., Bots, G.T.A.M. and Dom, R., Huntington's chorea: current neuropathologicai status. In T.N. Chase, N.X. Wexler and A. Barbeau (Eds.), Huntington's Dis-ease. Advances in Neurology, Vol. 23, Raven, New York, 1979, pp. 83-93. 8 Buck, S.H., Burks, T.F., Brown, M.R. and Yamamura, H.I., Reduction in basal ganglia and substantia nigra sub-stance P levels in Huntingtorfs disease, Brain Research, 209 (1981) 464-469. 9 Chen, F.M., Bilezikjian, L.M., Perrin, M.H., Rivier, J. and Vale, W., CRF receptor-mediated stimulation of ade-nylate cyclase activity in rat brain, Brain Research, 381 (1986) 49-57. 10 Dawbarn, D., DeQuidt, M.E. and Emson, P.C., Survival of basal ganglia neuropeptide Y/somatostatin neurones in Huntington's disease, Brain Research, 340 (1985) 251-260. 11 Dawbarn, D., Zamir, N., Waters, C.M., Hunt, S.P., Era-son, P.C. and Brownstein, M.J., Peptides derived from prodynorphin are decreased in basal ganglia of Hunting-ton's disease brains, Brain Research, 372 (1986) 155-158. 12 De Souza, E.B., Corticotropin-releasing factor receptors in the rat central nervous system: characterization and region-al distribution, J. Neurosci., 7 (1987) 88-100. 13 De Souza, E.B., Corticotropin-releasing factor, Comp. Ther., 11 (1985) 3-5. 14 De Souza, E.B., lnsel, T.R., Perrin, M.H., Rivier, J., Vale, W.W. and Kuhar, M.J., Corticotropin-releasing fac-tor receptors are widely distributed within the central ner-vous system: an autoradiographic study, J. Neurosci., 5 (198'~) 3189-3203. 15 De Souza, E.B. and Kuhar, M.J., Corticotropin-releasing factor receptors: autoradiographic identification. In J.B. Martin and J. Barchas (Eds.), Neuropeptides in Neurologic part by PHS Grants AN 26741 and HD 13527. Research was conducted in part by the Clayton Foundation for Research, California division. W.W.V. is a senior Clayton Foundation investigator. Funding Information: We thank Carolyn Douglas for technical assistance and Terrie Pierce and Mary Flutka for manuscript preparation. We thank the staff of the Center Without Walls for the Study of Huntington's Disease, particularly Mary Louise Franz for arranging the Huntington's disease autopsies. This study was supported by PHS Grants MH 2595 i, AG 03359, AG 05146, NS",
year = "1987",
month = dec,
day = "29",
doi = "10.1016/0006-8993(87)91651-9",
language = "English (US)",
volume = "437",
pages = "355--359",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}
