Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease

Errol B. De Souza; Peter J. Whitehouse; Susan E. Folstein; Donald L. Price; Wylie W. Vale

doi:10.1016/0006-8993(87)91651-9

Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease

Errol B. De Souza, Peter J. Whitehouse, Susan E. Folstein, Donald L. Price, Wylie W. Vale

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.

Original language	English (US)
Pages (from-to)	355-359
Number of pages	5
Journal	Brain Research
Volume	437
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)91651-9
State	Published - Dec 29 1987

Keywords

Basal ganglia
Corticotropin-releasing hormone
Huntington's disease
Postmortem human brain
Radioimmunoassay
Somatostatin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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title = "Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease",

abstract = "Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.",

keywords = "Basal ganglia, Corticotropin-releasing hormone, Huntington's disease, Postmortem human brain, Radioimmunoassay, Somatostatin",

author = "{De Souza}, {Errol B.} and Whitehouse, {Peter J.} and Folstein, {Susan E.} and Price, {Donald L.} and Vale, {Wylie W.}",

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AU - De Souza, Errol B.

AU - Whitehouse, Peter J.

AU - Folstein, Susan E.

AU - Price, Donald L.

AU - Vale, Wylie W.

PY - 1987/12/29

Y1 - 1987/12/29

N2 - Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.

AB - Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.

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KW - Corticotropin-releasing hormone

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KW - Postmortem human brain

KW - Radioimmunoassay

KW - Somatostatin

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