Corticotropin-releasing factor stimulates accumulation of adenosine 3′,5′-monophosphate in rat pituitary corticotrophs

Fernand Labrie, Raymonde Veilleux, Gerard Lefevre, David H. Coy, Javier Sueiras-Diaz, Andrew V. Schally

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Abstract

The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3',5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.

Original languageEnglish (US)
Pages (from-to)1007-1008
Number of pages2
JournalScience
Volume216
Issue number4549
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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