Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type: Reduced Cortical and Striatal Concentrations

Garth Bissette, Gavin P. Reynolds, Clinton D. Kilts, Erik Widerlöv, Charles Nemeroff

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the human central nervous system was measured by radioimmunoassay in postmortem tissue of control patients and in those with histologically confirmed senile dementia of the Alzheimer type (SDAT). In the controls, CRF-LI was found in high concentrations in the hypothalamus and frontal cortex (Brodmann's area 10), in moderate concentrations in amygdala, substantia innominata, temporal and parietal cortex (Brodmann's areas 38 and 7), and the caudate nucleus, and in low concentrations in posterior hippocampus and nucleus accumbens. A marked reduction in the concentration of CRF-LI was observed in the frontal and temporal cortex (approximately 50%) as well as in the caudate nucleus (approximately 70%) in the SDAT group. The present findings suggest that neurons containing corticotropinreleasing factor are pathologically altered in SDAT, in addition to the previously described cholinergic and somatostatinergic neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)3067-3069
Number of pages3
JournalJAMA - Journal of the American Medical Association
Volume254
Issue number21
DOIs
StatePublished - Dec 6 1985
Externally publishedYes

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Corpus Striatum
Corticotropin-Releasing Hormone
Alzheimer Disease
Caudate Nucleus
Frontal Lobe
Temporal Lobe
Substantia Innominata
Parietal Lobe
Nucleus Accumbens
Amygdala
Cholinergic Agents
Hypothalamus
Radioimmunoassay
Hippocampus
Central Nervous System
Neurons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type : Reduced Cortical and Striatal Concentrations. / Bissette, Garth; Reynolds, Gavin P.; Kilts, Clinton D.; Widerlöv, Erik; Nemeroff, Charles.

In: JAMA - Journal of the American Medical Association, Vol. 254, No. 21, 06.12.1985, p. 3067-3069.

Research output: Contribution to journalArticle

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