Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats

C. L. Ehlers; R. I. Chaplin; T. L. Wall; L. Lumeng; T. K. Li; M. J. Owens; C. B. Nemeroff

doi:10.1007/BF02245418

Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats

C. L. Ehlers, R. I. Chaplin, T. L. Wall, L. Lumeng, T. K. Li, M. J. Owens, C. B. Nemeroff

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Abstract

Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.

Original language	English (US)
Pages (from-to)	359-364
Number of pages	6
Journal	Psychopharmacology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1007/BF02245418
State	Published - Mar 1992
Externally published	Yes

Keywords

Alcohol-preferring rats
Corticotropin releasing factor (CRF)
Electroencephalogram (EEG)
Hypothalamic-pituitary-adrenal (HPA) axis
Spectral analysis

ASJC Scopus subject areas

Pharmacology

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10.1007/BF02245418

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title = "Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats",

abstract = "Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.",

keywords = "Alcohol-preferring rats, Corticotropin releasing factor (CRF), Electroencephalogram (EEG), Hypothalamic-pituitary-adrenal (HPA) axis, Spectral analysis",

author = "Ehlers, {C. L.} and Chaplin, {R. I.} and Wall, {T. L.} and L. Lumeng and Li, {T. K.} and Owens, {M. J.} and Nemeroff, {C. B.}",

year = "1992",

month = mar,

doi = "10.1007/BF02245418",

language = "English (US)",

volume = "106",

pages = "359--364",

journal = "Psychopharmacology",

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T2 - studies in alcohol preferring and non-preferring rats

AU - Ehlers, C. L.

AU - Chaplin, R. I.

AU - Wall, T. L.

AU - Lumeng, L.

AU - Li, T. K.

AU - Owens, M. J.

AU - Nemeroff, C. B.

PY - 1992/3

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N2 - Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.

AB - Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.

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Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats

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