Corticotropin releasing factor (CRF)

studies in alcohol preferring and non-preferring rats

C. L. Ehlers, R. I. Chaplin, T. L. Wall, L. Lumeng, T. K. Li, M. J. Owens, Charles Nemeroff

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalPsychopharmacology
Volume106
Issue number3
DOIs
StatePublished - Mar 1 1992
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Alcohols
Corticotropin-Releasing Hormone Receptors
Gyrus Cinguli
Frontal Lobe
Amygdala
Prefrontal Cortex
Hypothalamus
Analysis of Variance
Electrodes
Ethanol
Neurons
Brain

Keywords

  • Alcohol-preferring rats
  • Corticotropin releasing factor (CRF)
  • Electroencephalogram (EEG)
  • Hypothalamic-pituitary-adrenal (HPA) axis
  • Spectral analysis

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ehlers, C. L., Chaplin, R. I., Wall, T. L., Lumeng, L., Li, T. K., Owens, M. J., & Nemeroff, C. (1992). Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats. Psychopharmacology, 106(3), 359-364. https://doi.org/10.1007/BF02245418

Corticotropin releasing factor (CRF) : studies in alcohol preferring and non-preferring rats. / Ehlers, C. L.; Chaplin, R. I.; Wall, T. L.; Lumeng, L.; Li, T. K.; Owens, M. J.; Nemeroff, Charles.

In: Psychopharmacology, Vol. 106, No. 3, 01.03.1992, p. 359-364.

Research output: Contribution to journalArticle

Ehlers, CL, Chaplin, RI, Wall, TL, Lumeng, L, Li, TK, Owens, MJ & Nemeroff, C 1992, 'Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats', Psychopharmacology, vol. 106, no. 3, pp. 359-364. https://doi.org/10.1007/BF02245418
Ehlers CL, Chaplin RI, Wall TL, Lumeng L, Li TK, Owens MJ et al. Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats. Psychopharmacology. 1992 Mar 1;106(3):359-364. https://doi.org/10.1007/BF02245418
Ehlers, C. L. ; Chaplin, R. I. ; Wall, T. L. ; Lumeng, L. ; Li, T. K. ; Owens, M. J. ; Nemeroff, Charles. / Corticotropin releasing factor (CRF) : studies in alcohol preferring and non-preferring rats. In: Psychopharmacology. 1992 ; Vol. 106, No. 3. pp. 359-364.
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