Abstract
Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.
| Original language | English |
|---|---|
| Pages (from-to) | 359-364 |
| Number of pages | 6 |
| Journal | Psychopharmacology |
| Volume | 106 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 1992 |
| Externally published | Yes |
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Keywords
- Alcohol-preferring rats
- Corticotropin releasing factor (CRF)
- Electroencephalogram (EEG)
- Hypothalamic-pituitary-adrenal (HPA) axis
- Spectral analysis
ASJC Scopus subject areas
- Pharmacology
Cite this
Corticotropin releasing factor (CRF) : studies in alcohol preferring and non-preferring rats. / Ehlers, C. L.; Chaplin, R. I.; Wall, T. L.; Lumeng, L.; Li, T. K.; Owens, M. J.; Nemeroff, Charles.
In: Psychopharmacology, Vol. 106, No. 3, 01.03.1992, p. 359-364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corticotropin releasing factor (CRF)
T2 - studies in alcohol preferring and non-preferring rats
AU - Ehlers, C. L.
AU - Chaplin, R. I.
AU - Wall, T. L.
AU - Lumeng, L.
AU - Li, T. K.
AU - Owens, M. J.
AU - Nemeroff, Charles
PY - 1992/3/1
Y1 - 1992/3/1
N2 - Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.
AB - Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz, P<0.03; 6-8 Hz, P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines.
KW - Alcohol-preferring rats
KW - Corticotropin releasing factor (CRF)
KW - Electroencephalogram (EEG)
KW - Hypothalamic-pituitary-adrenal (HPA) axis
KW - Spectral analysis
UR - http://www.scopus.com/inward/record.url?scp=0026501345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026501345&partnerID=8YFLogxK
U2 - 10.1007/BF02245418
DO - 10.1007/BF02245418
M3 - Article
C2 - 1570383
AN - SCOPUS:0026501345
VL - 106
SP - 359
EP - 364
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -