Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety

D. A. Gutman, C. B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007

Original languageEnglish (US)
Title of host publicationEncyclopedia of Stress
PublisherElsevier Inc.
Pages630-634
Number of pages5
ISBN (Print)9780123739476
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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