Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety

D. A. Gutman; C. B. Nemeroff

doi:10.1016/B978-012373947-6.00454-2

Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety

D. A. Gutman, C. B. Nemeroff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007

Original language	English (US)
Title of host publication	Encyclopedia of Stress
Publisher	Elsevier Inc.
Pages	630-634
Number of pages	5
ISBN (Print)	9780123739476
DOIs	https://doi.org/10.1016/B978-012373947-6.00454-2
State	Published - Jan 1 2007
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-012373947-6.00454-2

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AU - Nemeroff, C. B.

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AB - Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007

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