Abstract
Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Stress |
| Publisher | Elsevier Inc. |
| Pages | 630-634 |
| Number of pages | 5 |
| ISBN (Print) | 9780123739476 |
| DOIs | |
| State | Published - Dec 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety. / Gutman, D. A.; Nemeroff, Charles.
Encyclopedia of Stress. Elsevier Inc., 2010. p. 630-634.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety
AU - Gutman, D. A.
AU - Nemeroff, Charles
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007
AB - Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans. CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH in turn stimulates the production and release of cortisol (the primary glucocorticoid in humans) from the adrenal cortex. Subsequently, a more widespread role for CRF in coordinating the stress response has been described. © 2007
UR - http://www.scopus.com/inward/record.url?scp=84882876423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882876423&partnerID=8YFLogxK
U2 - 10.1016/B978-012373947-6.00454-2
DO - 10.1016/B978-012373947-6.00454-2
M3 - Chapter
AN - SCOPUS:84882876423
SN - 9780123739476
SP - 630
EP - 634
BT - Encyclopedia of Stress
PB - Elsevier Inc.
ER -