Corticotropin-releasing factor and the psychobiology of early-life stress

Charles F. Gillespie, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Trauma and neglect during childhood are increasingly appreciated as factors in the etiology of adult mood and anxiety disorders. Much has been learned about the role of stress biology in the persisting effects of early adverse experience on adult psychopathology. Here we present an overview of developmental trauma in the psychobiology of depression and anxiety. We emphasize the role of corticotropin-releasing factor in the pathophysiology of these disorders, focusing on the transduction of early life trauma into adult psychopathology.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalCurrent Directions in Psychological Science
Issue number2
StatePublished - Apr 2007
Externally publishedYes


  • Corticotropin-releasing factor
  • Depression
  • Neglect
  • Stress
  • Trauma

ASJC Scopus subject areas

  • Psychology(all)


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