Corticotropin-releasing factor and the psychobiology of early-life stress

Charles F. Gillespie, Charles Nemeroff

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Trauma and neglect during childhood are increasingly appreciated as factors in the etiology of adult mood and anxiety disorders. Much has been learned about the role of stress biology in the persisting effects of early adverse experience on adult psychopathology. Here we present an overview of developmental trauma in the psychobiology of depression and anxiety. We emphasize the role of corticotropin-releasing factor in the pathophysiology of these disorders, focusing on the transduction of early life trauma into adult psychopathology.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalCurrent Directions in Psychological Science
Volume16
Issue number2
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Psychological Stress
Psychopathology
Wounds and Injuries
Anxiety Disorders
Mood Disorders
Anxiety
Depression

Keywords

  • Corticotropin-releasing factor
  • Depression
  • Neglect
  • Stress
  • Trauma

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Corticotropin-releasing factor and the psychobiology of early-life stress. / Gillespie, Charles F.; Nemeroff, Charles.

In: Current Directions in Psychological Science, Vol. 16, No. 2, 01.04.2007, p. 85-89.

Research output: Contribution to journalArticle

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