CORTICOTROPHIN RELEASING FACTOR: EFFECTS ON CIRCULATING GUT AND PANCREATIC PEPTIDES IN MAN

N. LYTRAS, A. GROSSMAN, LESLEY H. REES, A. V. SCHALLY, S. R. BLOOM, G. M. BESSER

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

As a CRF-like peptide has been isolated from human gut, we investigated the effect of synthetic CRF-41 100 μg on gut and pancreatic peptides in six normal subjects. There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. In addition, there was no change in circulating met-enkephalin. We conclude that the rise in pancreatic polypeptide seen after CRF administration may suggest a role for a CRF-like peptide in the control of pancreatic function.

Original languageEnglish (US)
Pages (from-to)725-729
Number of pages5
JournalClinical Endocrinology
Volume20
Issue number6
DOIs
StatePublished - Jun 1984

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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