Corticotrophin releasing factor: Effects on circulating gut and pancreatic peptides in man

N. Lytras, A. Grossman, L. H. Rees, Andrew V Schally, S. R. Bloom, G. M. Besser

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

As a CRF-like peptide has been isolated from human gut, we investigated the effect of synthetic CRF-41 100 μg on gut and pancreatic peptides in six normal subjects. There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. In addition, there was no change in circulating met-enkephalin. We conclude that the rise in pancreatic polypeptide seen after CRF administration may suggest a role for a CRF-like peptide in the control of pancreatic function.

Original languageEnglish
Pages (from-to)725-729
Number of pages5
JournalClinical Endocrinology
Volume20
Issue number6
StatePublished - Jul 19 1984
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Pancreatic Polypeptide
Peptides
Motilin
Neurotensin
Methionine Enkephalin
Cholecystokinin
Gastrins
Somatostatin
Glucagon
Stomach
Insulin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Lytras, N., Grossman, A., Rees, L. H., Schally, A. V., Bloom, S. R., & Besser, G. M. (1984). Corticotrophin releasing factor: Effects on circulating gut and pancreatic peptides in man. Clinical Endocrinology, 20(6), 725-729.

Corticotrophin releasing factor : Effects on circulating gut and pancreatic peptides in man. / Lytras, N.; Grossman, A.; Rees, L. H.; Schally, Andrew V; Bloom, S. R.; Besser, G. M.

In: Clinical Endocrinology, Vol. 20, No. 6, 19.07.1984, p. 725-729.

Research output: Contribution to journalArticle

Lytras, N, Grossman, A, Rees, LH, Schally, AV, Bloom, SR & Besser, GM 1984, 'Corticotrophin releasing factor: Effects on circulating gut and pancreatic peptides in man', Clinical Endocrinology, vol. 20, no. 6, pp. 725-729.
Lytras, N. ; Grossman, A. ; Rees, L. H. ; Schally, Andrew V ; Bloom, S. R. ; Besser, G. M. / Corticotrophin releasing factor : Effects on circulating gut and pancreatic peptides in man. In: Clinical Endocrinology. 1984 ; Vol. 20, No. 6. pp. 725-729.
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