Efeito do corticoesteróide sobre o perfil das interleucinas intestinais e hepáticas no modelo de gastrosquise em ratos

Translated title of the contribution: Corticosteroid effect upon intestinal and hepatic interleukin profile in a gastroschisis rat model

Frances Lilian Lanhellas Gonçalves, Daniel Guimarães Bittencourt, Lício Augusto Velloso, Augusto Frederico Schmidt, Rodrigo Melo Gallindo, Lourenço Sbragia

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

PURPOSE: To evaluate the effect of corticosteroids on intestinal and liver interleukin profile in an experimental model of gastroschisis in fetal rats. METHODS: Sprague-Dawley rats at 19.5 days of gestation had its fetuses operated for the creation of gastroschisis. Two groups of fetuses were studied with and without maternal administration of dexamethasone. Each group was composed of fetuses who underwent gastroschisis (G), control fetuses without manipulation (C) and sham fetuses (S). A dosage of the following interleukins was carried out in fetal intestinal and liver tissues: IL-1, IL-6, IL-10, tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ). The differences between the groups and subgroups were tested by ANOVA with Tukey post-test, with significant values of p<0.05. RESULTS: Dexamethasone led to an increase in intestinal and liver IL-6 (p<0.05) and a decrease in intestinal TNF-α (p<0.001) in fetuses with gastroschisis. CONCLUSION: Corticosteroids had an effect on the intestinal interleukin profile and a small effect on the liver interleukin profile due to immunological immaturity of the fetus, and also of fetuses with gastroschisis. The steroid action may not be exclusively antiinflammatory, but also pro-inflammatory, varying with time of pregnancy.

Translated title of the contributionCorticosteroid effect upon intestinal and hepatic interleukin profile in a gastroschisis rat model
Original languagePortuguese
Pages (from-to)8-12
Number of pages5
JournalActa Cirurgica Brasileira
Volume28
Issue numberSUPPL.1
StatePublished - 2013
Externally publishedYes

Keywords

  • Cytokines
  • Dexamethasone
  • Fetal development
  • Gastroschisis
  • Inflammation
  • Rats

ASJC Scopus subject areas

  • Surgery

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