Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation

Frank Cortazar, Roque Diaz-Wong, David Roth, Tamara Isakova

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft survival, and rates of death with a functioning allograft remain high. Long-term safety profiles of existing immunosuppressive regimens point to a need for continued search for alternative agents. This overview discusses emerging evidence on a few promising therapeutic approaches, juxtaposes conflicting findings and highlights remaining knowledge gaps.

Original languageEnglish
Pages (from-to)2708-2716
Number of pages9
JournalNephrology Dialysis Transplantation
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2013

Fingerprint

Kidney Transplantation
Allografts
Adrenal Cortex Hormones
Renal Replacement Therapy
Kidney Diseases
Graft Survival
Immunosuppressive Agents
Chronic Renal Insufficiency
Chronic Kidney Failure
Disease Progression
Cardiovascular Diseases
Survival Rate
Public Health
Kidney
Safety
Calcineurin Inhibitors
Therapeutics

Keywords

  • Belatacept
  • Corticosteroids
  • Mammalian target of rapamycin inhibitors

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation. / Cortazar, Frank; Diaz-Wong, Roque; Roth, David; Isakova, Tamara.

In: Nephrology Dialysis Transplantation, Vol. 28, No. 11, 01.11.2013, p. 2708-2716.

Research output: Contribution to journalArticle

Cortazar, Frank ; Diaz-Wong, Roque ; Roth, David ; Isakova, Tamara. / Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation. In: Nephrology Dialysis Transplantation. 2013 ; Vol. 28, No. 11. pp. 2708-2716.
@article{fc5cfced94fc4464aac50d1e4ae0dc8c,
title = "Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation",
abstract = "Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft survival, and rates of death with a functioning allograft remain high. Long-term safety profiles of existing immunosuppressive regimens point to a need for continued search for alternative agents. This overview discusses emerging evidence on a few promising therapeutic approaches, juxtaposes conflicting findings and highlights remaining knowledge gaps.",
keywords = "Belatacept, Corticosteroids, Mammalian target of rapamycin inhibitors",
author = "Frank Cortazar and Roque Diaz-Wong and David Roth and Tamara Isakova",
year = "2013",
month = "11",
day = "1",
doi = "10.1093/ndt/gft231",
language = "English",
volume = "28",
pages = "2708--2716",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation

AU - Cortazar, Frank

AU - Diaz-Wong, Roque

AU - Roth, David

AU - Isakova, Tamara

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft survival, and rates of death with a functioning allograft remain high. Long-term safety profiles of existing immunosuppressive regimens point to a need for continued search for alternative agents. This overview discusses emerging evidence on a few promising therapeutic approaches, juxtaposes conflicting findings and highlights remaining knowledge gaps.

AB - Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft survival, and rates of death with a functioning allograft remain high. Long-term safety profiles of existing immunosuppressive regimens point to a need for continued search for alternative agents. This overview discusses emerging evidence on a few promising therapeutic approaches, juxtaposes conflicting findings and highlights remaining knowledge gaps.

KW - Belatacept

KW - Corticosteroids

KW - Mammalian target of rapamycin inhibitors

UR - http://www.scopus.com/inward/record.url?scp=84890026656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890026656&partnerID=8YFLogxK

U2 - 10.1093/ndt/gft231

DO - 10.1093/ndt/gft231

M3 - Article

VL - 28

SP - 2708

EP - 2716

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 11

ER -