Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder

K. Luan Phan, Jennifer C Britton, Stephan F. Taylor, Lorraine M. Fig, Israel Liberzon

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Context: Recent brain imaging studies implicate dysfunction of limbic and paralimbic circuitry, including the amygdala and medial prefrontal cortex (MPFC), in the pathogenesis of posttraumatic stress disorder (PTSD) during traumatic recollection and imagery. However, the relationship between activity in these regions and general emotional processing unrelated to traumatic experience has not been fully examined. Objective: To investigate activity in the limbic and paralimbic brain regions in PTSD in response to a challenge with emotionally salient generic visual images. Design: Cross-sectional, case-control study. Setting: Academic medical center. Participants: Sixteen Vietnam veterans with combatrelated PTSD (PTSD group), 15 combat-exposed Vietnam veterans without PTSD(combat control group), and 15 age-and sex-matched healthy controls (normal control group). Main Outcome Measures: We used positron emission tomography to study regional cerebral blood flow while participants viewed complex visual pictures with negatively valenced/aversive, nonaversive ("neutral"), and blank pictures. Psychophysiologic and emotional selfreport data were also recorded. Results: All 3 groups activated the dorsal MPFC to general salient content. Controls without PTSD activated the left amygdala in response to aversive stimuli. Normal controls activated the ventral MPFC and combat-exposed non-PTSD and PTSD participants exhibited either no response or deactivation in these regions, respectively, during negative emotional experience. Conclusions: Consistent with current functional neuroanatomic models, patients with PTSD exhibited altered neural responses in the amygdala and ventral MPFC during the processing of emotionally salient but trauma-unrelated stimuli, potentially reflecting disorderspecific changes. Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD.

Original languageEnglish
Pages (from-to)184-192
Number of pages9
JournalArchives of General Psychiatry
Volume63
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Fingerprint

Post-Traumatic Stress Disorders
Prefrontal Cortex
Amygdala
Vietnam
Veterans
Cerebrovascular Circulation
Control Groups
Imagery (Psychotherapy)
Regional Blood Flow
Wounds and Injuries
Neuroimaging
Positron-Emission Tomography
Case-Control Studies
Outcome Assessment (Health Care)
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. / Luan Phan, K.; Britton, Jennifer C; Taylor, Stephan F.; Fig, Lorraine M.; Liberzon, Israel.

In: Archives of General Psychiatry, Vol. 63, No. 2, 01.02.2006, p. 184-192.

Research output: Contribution to journalArticle

Luan Phan, K. ; Britton, Jennifer C ; Taylor, Stephan F. ; Fig, Lorraine M. ; Liberzon, Israel. / Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. In: Archives of General Psychiatry. 2006 ; Vol. 63, No. 2. pp. 184-192.
@article{bc833247fda149eb9acb090c895162fc,
title = "Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder",
abstract = "Context: Recent brain imaging studies implicate dysfunction of limbic and paralimbic circuitry, including the amygdala and medial prefrontal cortex (MPFC), in the pathogenesis of posttraumatic stress disorder (PTSD) during traumatic recollection and imagery. However, the relationship between activity in these regions and general emotional processing unrelated to traumatic experience has not been fully examined. Objective: To investigate activity in the limbic and paralimbic brain regions in PTSD in response to a challenge with emotionally salient generic visual images. Design: Cross-sectional, case-control study. Setting: Academic medical center. Participants: Sixteen Vietnam veterans with combatrelated PTSD (PTSD group), 15 combat-exposed Vietnam veterans without PTSD(combat control group), and 15 age-and sex-matched healthy controls (normal control group). Main Outcome Measures: We used positron emission tomography to study regional cerebral blood flow while participants viewed complex visual pictures with negatively valenced/aversive, nonaversive ({"}neutral{"}), and blank pictures. Psychophysiologic and emotional selfreport data were also recorded. Results: All 3 groups activated the dorsal MPFC to general salient content. Controls without PTSD activated the left amygdala in response to aversive stimuli. Normal controls activated the ventral MPFC and combat-exposed non-PTSD and PTSD participants exhibited either no response or deactivation in these regions, respectively, during negative emotional experience. Conclusions: Consistent with current functional neuroanatomic models, patients with PTSD exhibited altered neural responses in the amygdala and ventral MPFC during the processing of emotionally salient but trauma-unrelated stimuli, potentially reflecting disorderspecific changes. Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD.",
author = "{Luan Phan}, K. and Britton, {Jennifer C} and Taylor, {Stephan F.} and Fig, {Lorraine M.} and Israel Liberzon",
year = "2006",
month = "2",
day = "1",
doi = "10.1001/archpsyc.63.2.184",
language = "English",
volume = "63",
pages = "184--192",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder

AU - Luan Phan, K.

AU - Britton, Jennifer C

AU - Taylor, Stephan F.

AU - Fig, Lorraine M.

AU - Liberzon, Israel

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Context: Recent brain imaging studies implicate dysfunction of limbic and paralimbic circuitry, including the amygdala and medial prefrontal cortex (MPFC), in the pathogenesis of posttraumatic stress disorder (PTSD) during traumatic recollection and imagery. However, the relationship between activity in these regions and general emotional processing unrelated to traumatic experience has not been fully examined. Objective: To investigate activity in the limbic and paralimbic brain regions in PTSD in response to a challenge with emotionally salient generic visual images. Design: Cross-sectional, case-control study. Setting: Academic medical center. Participants: Sixteen Vietnam veterans with combatrelated PTSD (PTSD group), 15 combat-exposed Vietnam veterans without PTSD(combat control group), and 15 age-and sex-matched healthy controls (normal control group). Main Outcome Measures: We used positron emission tomography to study regional cerebral blood flow while participants viewed complex visual pictures with negatively valenced/aversive, nonaversive ("neutral"), and blank pictures. Psychophysiologic and emotional selfreport data were also recorded. Results: All 3 groups activated the dorsal MPFC to general salient content. Controls without PTSD activated the left amygdala in response to aversive stimuli. Normal controls activated the ventral MPFC and combat-exposed non-PTSD and PTSD participants exhibited either no response or deactivation in these regions, respectively, during negative emotional experience. Conclusions: Consistent with current functional neuroanatomic models, patients with PTSD exhibited altered neural responses in the amygdala and ventral MPFC during the processing of emotionally salient but trauma-unrelated stimuli, potentially reflecting disorderspecific changes. Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD.

AB - Context: Recent brain imaging studies implicate dysfunction of limbic and paralimbic circuitry, including the amygdala and medial prefrontal cortex (MPFC), in the pathogenesis of posttraumatic stress disorder (PTSD) during traumatic recollection and imagery. However, the relationship between activity in these regions and general emotional processing unrelated to traumatic experience has not been fully examined. Objective: To investigate activity in the limbic and paralimbic brain regions in PTSD in response to a challenge with emotionally salient generic visual images. Design: Cross-sectional, case-control study. Setting: Academic medical center. Participants: Sixteen Vietnam veterans with combatrelated PTSD (PTSD group), 15 combat-exposed Vietnam veterans without PTSD(combat control group), and 15 age-and sex-matched healthy controls (normal control group). Main Outcome Measures: We used positron emission tomography to study regional cerebral blood flow while participants viewed complex visual pictures with negatively valenced/aversive, nonaversive ("neutral"), and blank pictures. Psychophysiologic and emotional selfreport data were also recorded. Results: All 3 groups activated the dorsal MPFC to general salient content. Controls without PTSD activated the left amygdala in response to aversive stimuli. Normal controls activated the ventral MPFC and combat-exposed non-PTSD and PTSD participants exhibited either no response or deactivation in these regions, respectively, during negative emotional experience. Conclusions: Consistent with current functional neuroanatomic models, patients with PTSD exhibited altered neural responses in the amygdala and ventral MPFC during the processing of emotionally salient but trauma-unrelated stimuli, potentially reflecting disorderspecific changes. Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD.

UR - http://www.scopus.com/inward/record.url?scp=32244439287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32244439287&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.63.2.184

DO - 10.1001/archpsyc.63.2.184

M3 - Article

C2 - 16461862

AN - SCOPUS:32244439287

VL - 63

SP - 184

EP - 192

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 2

ER -