Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease

Bárbara Duarte-Abritta, Mirta F. Villarreal, Carolina Abulafia, David Loewenstein, Rosie Curiel Cid, Mariana N. Castro, Ezequiel Surace, Stella Maris Sánchez, Daniel E. Vigo, Silvia Vázquez, Charles Nemeroff, Gustavo Sevlever, Salvador M. Guinjoan

Research output: Contribution to journalArticle

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Abstract

The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD. We obtained 3T T1 images for gray matter volume, FDG-PET to evaluate regional cerebral metabolism, and PET-PiB to detect fibrillar amyloid deposition in 30 middle-aged, asymptomatic, cognitively normal individuals with one parent diagnosed with LOAD (O-LOAD), and 25 comparable controls (CS) without family history of neurodegenerative disorders (CS). We observed isocortical thinning in AD-relevant areas including posterior cingulate, precuneus, and areas of the prefrontal and temporoparietal cortex in O-LOAD. Unexpectedly, this group displayed increased cerebral metabolism, in some cases overlapping with the areas of cortical thinning, and no differences in bilateral hippocampal volume and hippocampal metabolism. Given the importance of age in this sample of individuals potentially developing early AD-related changes, we controlled results for age and observed that most differences in cortical thickness and metabolism became nonsignificant; however, greater deposition of β-amyloid was observed in the right hemisphere including temporoparietal cortex, postcentral gyrus, fusiform inferior and middle temporal and lingual gyri. If replicated, the present observations of morphological, metabolic, and amyloid changes in cognitively normal persons with family history of LOAD may bear important implications for the definition of very early phenotypes of this disorder.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalJournal of Psychiatric Research
Volume107
DOIs
StatePublished - Dec 1 2018

Fingerprint

Amyloid
Alzheimer Disease
Brain
Gyrus Cinguli
Occipital Lobe
Parietal Lobe
Somatosensory Cortex
Temporal Lobe
Prefrontal Cortex
Neurodegenerative Diseases
Phenotype

Keywords

  • Alzheimer's disease
  • ApoE4
  • Cortical thickness
  • FDG-PET
  • PET-PiB

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease. / Duarte-Abritta, Bárbara; Villarreal, Mirta F.; Abulafia, Carolina; Loewenstein, David; Curiel Cid, Rosie; Castro, Mariana N.; Surace, Ezequiel; Sánchez, Stella Maris; Vigo, Daniel E.; Vázquez, Silvia; Nemeroff, Charles; Sevlever, Gustavo; Guinjoan, Salvador M.

In: Journal of Psychiatric Research, Vol. 107, 01.12.2018, p. 11-18.

Research output: Contribution to journalArticle

Duarte-Abritta, Bárbara ; Villarreal, Mirta F. ; Abulafia, Carolina ; Loewenstein, David ; Curiel Cid, Rosie ; Castro, Mariana N. ; Surace, Ezequiel ; Sánchez, Stella Maris ; Vigo, Daniel E. ; Vázquez, Silvia ; Nemeroff, Charles ; Sevlever, Gustavo ; Guinjoan, Salvador M. / Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease. In: Journal of Psychiatric Research. 2018 ; Vol. 107. pp. 11-18.
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AU - Villarreal, Mirta F.

AU - Abulafia, Carolina

AU - Loewenstein, David

AU - Curiel Cid, Rosie

AU - Castro, Mariana N.

AU - Surace, Ezequiel

AU - Sánchez, Stella Maris

AU - Vigo, Daniel E.

AU - Vázquez, Silvia

AU - Nemeroff, Charles

AU - Sevlever, Gustavo

AU - Guinjoan, Salvador M.

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