Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations

Spiridon Papapetropoulos, Donald S. McCorquodale, Jocely Gonzalez, Lucie Jean-Gilles, Deborah C Mash

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Visual hallucinations (VH) are among the most common non-motor complications of Parkinson's disease (PD). A few studies on their etiopathogenesis have suggested involvement of cortical and amygdalar areas. In order to investigate the possible association between extranigral Lewy Body (LB) distribution across cortical and amygdalar regions and the presence of VH in PD brain donors, we conducted a clinico-pathological comparison of 10 PD patients with VH vs 10 closely matched PD patients without VH. The LB burden was significantly higher across the amygdala and the frontal, temporal and parietal cortical areas in patients with VH. Although our results suggest significant extranigral involvement, the precise etiopathologic mechanisms responsible for the development of VH need further clarification.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalParkinsonism and Related Disorders
Volume12
Issue number4
DOIs
StatePublished - May 1 2006

Fingerprint

Body Burden
Lewy Bodies
Hallucinations
Parkinson Disease
Amygdala
Tissue Donors
Brain

Keywords

  • Amygdala
  • Cortex
  • Neuropathology
  • Parkinson's disease
  • Post-mortem
  • Visual Hallucinations

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. / Papapetropoulos, Spiridon; McCorquodale, Donald S.; Gonzalez, Jocely; Jean-Gilles, Lucie; Mash, Deborah C.

In: Parkinsonism and Related Disorders, Vol. 12, No. 4, 01.05.2006, p. 253-256.

Research output: Contribution to journalArticle

Papapetropoulos, Spiridon ; McCorquodale, Donald S. ; Gonzalez, Jocely ; Jean-Gilles, Lucie ; Mash, Deborah C. / Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. In: Parkinsonism and Related Disorders. 2006 ; Vol. 12, No. 4. pp. 253-256.
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