Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groups

C. B. Saper, Carol Petito

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

We have described a system of neurons containing a pigment with the empirical staining properties of melanin and which is likely to be identical with the human catecholamine neuron system. It would clearly be preferable to identify the human catecholaminergic neurons by immunohistochemical staining for tyrosine hydroxylase (see Hartman, 1974; Pickel, Hervonen, Joh and Reis, 1980), and this work is underway in our laboratory. Until such confirmation is available, it seems reasonable to use the pattern of melanin pigmentation (which is most easily recognized in thick, e.g. 50 μm, sections) as a method to assess the integrity of the human central catecholamine system. The present work provides a detailed map of the normal adult melanin pigmentation system against which to judge the brains of patients with various pathological conditions.

Original languageEnglish
Pages (from-to)87-101
Number of pages15
JournalBrain
Volume105
Issue number1
StatePublished - Dec 1 1982
Externally publishedYes

Fingerprint

Melanin
Catecholamines
Melanins
catecholamines
melanin
Neurons
Neuron
Brain
Correspondence
neurons
Pigmentation
brain
pigmentation
tyrosine 3-monooxygenase
Cell
Staining and Labeling
Tyrosine 3-Monooxygenase
cells
Pigments
pigments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groups. / Saper, C. B.; Petito, Carol.

In: Brain, Vol. 105, No. 1, 01.12.1982, p. 87-101.

Research output: Contribution to journalArticle

Saper, C. B. ; Petito, Carol. / Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groups. In: Brain. 1982 ; Vol. 105, No. 1. pp. 87-101.
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