Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography

Yingying Shi, Qinqin Zhang, Fang Zheng, Jonathan F. Russell, Elie H. Motulsky, James T. Banta, Zhongdi Chu, Hao Zhou, Nimesh A. Patel, Luis de Sisternes, Mary K. Durbin, William Feuer, Giovanni Gregori, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticle

Abstract

Purpose: Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomographic angiography (SS-OCTA) was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within the given macular regions. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) using both 3×3-mm and 6×6-mm macular scan patterns. The CC images were generated using a previously published and validated algorithm. In both 3×3-mm and 6×6-mm scans, the CC FD% and FDa were measured in circular regions centered on the fovea with diameters as 1 mm and 2.5 mm (C1 and C2.5). In 6×6-mm scans, the FD% and FDa were measured within an additional circular region with diameter as 5 mm (C5). The correlations between FD% and FDa from each region were analyzed with Pearson correlation coefficients. Results: A total of 164 eyes were analyzed. There was excellent correlation between CC FDa and FD% measurements from each region. In the 3×3-mm scans, the correlations in the C1 and C2.5 regions were 0.83 and 0.90, respectively. In the 6×6-mm scans, the correlations in C1, C2.5, and C5 regions were 0.90, 0.89, and 0.89, respectively. Conclusions: When measuring CC FDs, we found excellent correlations between FDa and FD% in regions from 3×3-mm and 6×6-mm scans. Further studies are needed to determine if one parameter is more useful when studying diseased eyes.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalAmerican journal of ophthalmology
Volume209
DOIs
StatePublished - Jan 2020

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Angiography
Eye Diseases
Cross-Sectional Studies

ASJC Scopus subject areas

  • Ophthalmology

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Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography. / Shi, Yingying; Zhang, Qinqin; Zheng, Fang; Russell, Jonathan F.; Motulsky, Elie H.; Banta, James T.; Chu, Zhongdi; Zhou, Hao; Patel, Nimesh A.; de Sisternes, Luis; Durbin, Mary K.; Feuer, William; Gregori, Giovanni; Wang, Ruikang K.; Rosenfeld, Philip J.

In: American journal of ophthalmology, Vol. 209, 01.2020, p. 18-26.

Research output: Contribution to journalArticle

Shi, Y, Zhang, Q, Zheng, F, Russell, JF, Motulsky, EH, Banta, JT, Chu, Z, Zhou, H, Patel, NA, de Sisternes, L, Durbin, MK, Feuer, W, Gregori, G, Wang, RK & Rosenfeld, PJ 2020, 'Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography', American journal of ophthalmology, vol. 209, pp. 18-26. https://doi.org/10.1016/j.ajo.2019.09.017
Shi, Yingying ; Zhang, Qinqin ; Zheng, Fang ; Russell, Jonathan F. ; Motulsky, Elie H. ; Banta, James T. ; Chu, Zhongdi ; Zhou, Hao ; Patel, Nimesh A. ; de Sisternes, Luis ; Durbin, Mary K. ; Feuer, William ; Gregori, Giovanni ; Wang, Ruikang K. ; Rosenfeld, Philip J. / Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography. In: American journal of ophthalmology. 2020 ; Vol. 209. pp. 18-26.
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title = "Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography",
abstract = "Purpose: Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomographic angiography (SS-OCTA) was performed, and the percentage of CC flow deficits (FD{\%}) and the average area of CC flow deficits (FDa) were compared within the given macular regions. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) using both 3×3-mm and 6×6-mm macular scan patterns. The CC images were generated using a previously published and validated algorithm. In both 3×3-mm and 6×6-mm scans, the CC FD{\%} and FDa were measured in circular regions centered on the fovea with diameters as 1 mm and 2.5 mm (C1 and C2.5). In 6×6-mm scans, the FD{\%} and FDa were measured within an additional circular region with diameter as 5 mm (C5). The correlations between FD{\%} and FDa from each region were analyzed with Pearson correlation coefficients. Results: A total of 164 eyes were analyzed. There was excellent correlation between CC FDa and FD{\%} measurements from each region. In the 3×3-mm scans, the correlations in the C1 and C2.5 regions were 0.83 and 0.90, respectively. In the 6×6-mm scans, the correlations in C1, C2.5, and C5 regions were 0.90, 0.89, and 0.89, respectively. Conclusions: When measuring CC FDs, we found excellent correlations between FDa and FD{\%} in regions from 3×3-mm and 6×6-mm scans. Further studies are needed to determine if one parameter is more useful when studying diseased eyes.",
author = "Yingying Shi and Qinqin Zhang and Fang Zheng and Russell, {Jonathan F.} and Motulsky, {Elie H.} and Banta, {James T.} and Zhongdi Chu and Hao Zhou and Patel, {Nimesh A.} and {de Sisternes}, Luis and Durbin, {Mary K.} and William Feuer and Giovanni Gregori and Wang, {Ruikang K.} and Rosenfeld, {Philip J.}",
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T1 - Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography

AU - Shi, Yingying

AU - Zhang, Qinqin

AU - Zheng, Fang

AU - Russell, Jonathan F.

AU - Motulsky, Elie H.

AU - Banta, James T.

AU - Chu, Zhongdi

AU - Zhou, Hao

AU - Patel, Nimesh A.

AU - de Sisternes, Luis

AU - Durbin, Mary K.

AU - Feuer, William

AU - Gregori, Giovanni

AU - Wang, Ruikang K.

AU - Rosenfeld, Philip J.

PY - 2020/1

Y1 - 2020/1

N2 - Purpose: Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomographic angiography (SS-OCTA) was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within the given macular regions. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) using both 3×3-mm and 6×6-mm macular scan patterns. The CC images were generated using a previously published and validated algorithm. In both 3×3-mm and 6×6-mm scans, the CC FD% and FDa were measured in circular regions centered on the fovea with diameters as 1 mm and 2.5 mm (C1 and C2.5). In 6×6-mm scans, the FD% and FDa were measured within an additional circular region with diameter as 5 mm (C5). The correlations between FD% and FDa from each region were analyzed with Pearson correlation coefficients. Results: A total of 164 eyes were analyzed. There was excellent correlation between CC FDa and FD% measurements from each region. In the 3×3-mm scans, the correlations in the C1 and C2.5 regions were 0.83 and 0.90, respectively. In the 6×6-mm scans, the correlations in C1, C2.5, and C5 regions were 0.90, 0.89, and 0.89, respectively. Conclusions: When measuring CC FDs, we found excellent correlations between FDa and FD% in regions from 3×3-mm and 6×6-mm scans. Further studies are needed to determine if one parameter is more useful when studying diseased eyes.

AB - Purpose: Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomographic angiography (SS-OCTA) was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within the given macular regions. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) using both 3×3-mm and 6×6-mm macular scan patterns. The CC images were generated using a previously published and validated algorithm. In both 3×3-mm and 6×6-mm scans, the CC FD% and FDa were measured in circular regions centered on the fovea with diameters as 1 mm and 2.5 mm (C1 and C2.5). In 6×6-mm scans, the FD% and FDa were measured within an additional circular region with diameter as 5 mm (C5). The correlations between FD% and FDa from each region were analyzed with Pearson correlation coefficients. Results: A total of 164 eyes were analyzed. There was excellent correlation between CC FDa and FD% measurements from each region. In the 3×3-mm scans, the correlations in the C1 and C2.5 regions were 0.83 and 0.90, respectively. In the 6×6-mm scans, the correlations in C1, C2.5, and C5 regions were 0.90, 0.89, and 0.89, respectively. Conclusions: When measuring CC FDs, we found excellent correlations between FDa and FD% in regions from 3×3-mm and 6×6-mm scans. Further studies are needed to determine if one parameter is more useful when studying diseased eyes.

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