Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography

Yingying Shi, Qinqin Zhang, Fang Zheng, Jonathan F. Russell, Elie H. Motulsky, James T. Banta, Zhongdi Chu, Hao Zhou, Nimesh A. Patel, Luis de Sisternes, Mary K. Durbin, William J Feuer, Giovanni Gregori, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomographic angiography (SS-OCTA) was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within the given macular regions. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) using both 3×3-mm and 6×6-mm macular scan patterns. The CC images were generated using a previously published and validated algorithm. In both 3×3-mm and 6×6-mm scans, the CC FD% and FDa were measured in circular regions centered on the fovea with diameters as 1 mm and 2.5 mm (C1 and C2.5). In 6×6-mm scans, the FD% and FDa were measured within an additional circular region with diameter as 5 mm (C5). The correlations between FD% and FDa from each region were analyzed with Pearson correlation coefficients. Results: A total of 164 eyes were analyzed. There was excellent correlation between CC FDa and FD% measurements from each region. In the 3×3-mm scans, the correlations in the C1 and C2.5 regions were 0.83 and 0.90, respectively. In the 6×6-mm scans, the correlations in C1, C2.5, and C5 regions were 0.90, 0.89, and 0.89, respectively. Conclusions: When measuring CC FDs, we found excellent correlations between FDa and FD% in regions from 3×3-mm and 6×6-mm scans. Further studies are needed to determine if one parameter is more useful when studying diseased eyes.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalAmerican journal of ophthalmology
Volume209
DOIs
StatePublished - Jan 2020

ASJC Scopus subject areas

  • Ophthalmology

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    Shi, Y., Zhang, Q., Zheng, F., Russell, J. F., Motulsky, E. H., Banta, J. T., Chu, Z., Zhou, H., Patel, N. A., de Sisternes, L., Durbin, M. K., Feuer, W. J., Gregori, G., Wang, R. K., & Rosenfeld, P. J. (2020). Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography. American journal of ophthalmology, 209, 18-26. https://doi.org/10.1016/j.ajo.2019.09.017