TY - JOUR
T1 - Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy Using Swept Source OCTImaging
AU - Shi, Yingying
AU - Zhang, Qinqin
AU - Zhou, Hao
AU - Wang, Liang
AU - Chu, Zhongdi
AU - Jiang, Xiaoshuang
AU - Shen, Mengxi
AU - Thulliez, Marie
AU - Lyu, Cancan
AU - Feuer, William
AU - de Sisternes, Luis
AU - Durbin, Mary K.
AU - Gregori, Giovanni
AU - Wang, Ruikang K.
AU - Rosenfeld, Philip J.
N1 - Funding Information:
All authors completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Publication of this article was supported by National Eye Institute grant R01EY028753, Carl Zeiss Meditec, Dubin, CA, United States, the Salah Foundation, an unrestricted grant from Research to Prevent Blindness, Inc., and National Eye Institute Center Core grant P30EY014801 to the Department of Ophthalmology, University of Miami Miller School of Medicine. The funding organizations had no role in the design or conduct of this research. Financial Disclosures: Giovanni Gregori, Liang Wang, and Philip J. Rosenfeld received research support from Carl Zeiss Meditec, Inc. Giovanni Gregori and the University of Miami co-own a patent licensed to Carl Zeiss Meditec, Inc. Philip J. Rosenfeld also receives additional research funding from Stealth BioTherapeutics; and is a consultant for Apellis, Biogen, Boehringer Ingelheim, Carl Zeiss Meditec, Chengdu Kanghong Biotech, EyePoint, Ocunexus Therapeutics, Ocudyne, and Unity Biotechnology; and holds equity interest in Apellis, Valitor, Verana Health, and Ocudyne. Liang Wang holds intellectual property owned by the Oregon Health and Science University and University of Washington; and receives research support from Moptim Inc. Colgate Palmolive Company, and Facebook Technologies LLC; and is a consultant for Insight Photonic Solutions, Kowa, and Carl Zeiss Meditec. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Funding Information:
All authors completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Publication of this article was supported by National Eye Institute grant R01EY028753 , Carl Zeiss Meditec , Dubin, CA, United States, the Salah Foundation, an unrestricted grant from Research to Prevent Blindness, Inc. , and National Eye Institute Center Core grant P30EY014801 to the Department of Ophthalmology, University of Miami Miller School of Medicine. The funding organizations had no role in the design or conduct of this research.
Funding Information:
Financial Disclosures: Giovanni Gregori, Liang Wang, and Philip J. Rosenfeld received research support from Carl Zeiss Meditec, Inc. Giovanni Gregori and the University of Miami co-own a patent licensed to Carl Zeiss Meditec, Inc. Philip J. Rosenfeld also receives additional research funding from Stealth BioTherapeutics; and is a consultant for Apellis, Biogen, Boehringer Ingelheim, Carl Zeiss Meditec, Chengdu Kanghong Biotech, EyePoint, Ocunexus Therapeutics, Ocudyne, and Unity Biotechnology; and holds equity interest in Apellis, Valitor, Verana Health, and Ocudyne. Liang Wang holds intellectual property owned by the Oregon Health and Science University and University of Washington; and receives research support from Moptim Inc., Colgate Palmolive Company, and Facebook Technologies LLC; and is a consultant for Insight Photonic Solutions, Kowa, and Carl Zeiss Meditec. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/4
Y1 - 2021/4
N2 - Purpose: Correlations among enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source-optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design: A retrospective review of prospective, observational case series. Methods: Eyes with GA from AMD were imaged with SS-OCT using 6 × 6-mm scan pattern. GA lesions were identified and measured using customized en face structural images, and annual square root ERs of GA were calculated. At baseline, choriocapillaris FDs from different regions outside the GA were measured, and MCT and CVI from the entire scan area were measured. All measurements were performed using previously published and validated algorithms. Results: A total of 38 eyes from 27 patients were included. The CC FDs within each region around GA lesions were highly correlated with ERs of GA (all P < .005). CVI inside the GA region was correlated with the ERs (P = .03), whereas other choroidal measurements had no significant correlation with the ERs of GA (P >. 06). Conclusions: Statistically significant correlations were found between the ERs of GA and CC percentage of FD (FD%) from the entire scan region outside the GA and not just the region immediately adjacent to the GA. These results suggest that abnormal CC perfusion throughout the macula contributes to disease progression in eyes with GA. CVI inside the GA region could also be a potential indicator for the growth of GA.
AB - Purpose: Correlations among enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source-optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design: A retrospective review of prospective, observational case series. Methods: Eyes with GA from AMD were imaged with SS-OCT using 6 × 6-mm scan pattern. GA lesions were identified and measured using customized en face structural images, and annual square root ERs of GA were calculated. At baseline, choriocapillaris FDs from different regions outside the GA were measured, and MCT and CVI from the entire scan area were measured. All measurements were performed using previously published and validated algorithms. Results: A total of 38 eyes from 27 patients were included. The CC FDs within each region around GA lesions were highly correlated with ERs of GA (all P < .005). CVI inside the GA region was correlated with the ERs (P = .03), whereas other choroidal measurements had no significant correlation with the ERs of GA (P >. 06). Conclusions: Statistically significant correlations were found between the ERs of GA and CC percentage of FD (FD%) from the entire scan region outside the GA and not just the region immediately adjacent to the GA. These results suggest that abnormal CC perfusion throughout the macula contributes to disease progression in eyes with GA. CVI inside the GA region could also be a potential indicator for the growth of GA.
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U2 - 10.1016/j.ajo.2020.12.015
DO - 10.1016/j.ajo.2020.12.015
M3 - Article
C2 - 33359715
AN - SCOPUS:85101371499
VL - 224
SP - 321
EP - 331
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -