Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy Using Swept Source OCTImaging

Yingying Shi, Qinqin Zhang, Hao Zhou, Liang Wang, Zhongdi Chu, Xiaoshuang Jiang, Mengxi Shen, Marie Thulliez, Cancan Lyu, William Feuer, Luis de Sisternes, Mary K. Durbin, Giovanni Gregori, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review


Purpose: Correlations among enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source-optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design: A retrospective review of prospective, observational case series. Methods: Eyes with GA from AMD were imaged with SS-OCT using 6 × 6-mm scan pattern. GA lesions were identified and measured using customized en face structural images, and annual square root ERs of GA were calculated. At baseline, choriocapillaris FDs from different regions outside the GA were measured, and MCT and CVI from the entire scan area were measured. All measurements were performed using previously published and validated algorithms. Results: A total of 38 eyes from 27 patients were included. The CC FDs within each region around GA lesions were highly correlated with ERs of GA (all P < .005). CVI inside the GA region was correlated with the ERs (P = .03), whereas other choroidal measurements had no significant correlation with the ERs of GA (P >. 06). Conclusions: Statistically significant correlations were found between the ERs of GA and CC percentage of FD (FD%) from the entire scan region outside the GA and not just the region immediately adjacent to the GA. These results suggest that abnormal CC perfusion throughout the macula contributes to disease progression in eyes with GA. CVI inside the GA region could also be a potential indicator for the growth of GA.

Original languageEnglish (US)
Pages (from-to)321-331
Number of pages11
JournalAmerican journal of ophthalmology
StatePublished - Apr 2021

ASJC Scopus subject areas

  • Ophthalmology


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