Correlation of tumor growth and cell mediated immune responses of mice bearing mammary tumors following surgical procedures

Diana M Lopez, M. M. Sigel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Following surgical removal of transplantable mammary tumors some mice remained tumor free, while in others there was a regrowth of tumor. There was a correlation between lymphocyte responses to tumor antigens and mitogens and the clinical course subsequent to surgery. The highest responses occurred in lymphocytes from mice free of tumors or with small tumors. Animals in which tumors regenerated had diminished responses and the degree of diminution corresponded to the size of the tumor. Restoration of lymphocyte responses followed not only surgery but partial restoration was also observed after sham surgery. The implications of these findings are discussed.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalRES Journal of the Reticuloendothelial Society
Volume18
Issue number5
StatePublished - Dec 1 1975

Fingerprint

Breast Neoplasms
Growth
Neoplasms
Lymphocytes
Neoplasm Antigens
Mitogens

ASJC Scopus subject areas

  • Hematology

Cite this

@article{7510f2c727ba494ab2e9071e540118a9,
title = "Correlation of tumor growth and cell mediated immune responses of mice bearing mammary tumors following surgical procedures",
abstract = "Following surgical removal of transplantable mammary tumors some mice remained tumor free, while in others there was a regrowth of tumor. There was a correlation between lymphocyte responses to tumor antigens and mitogens and the clinical course subsequent to surgery. The highest responses occurred in lymphocytes from mice free of tumors or with small tumors. Animals in which tumors regenerated had diminished responses and the degree of diminution corresponded to the size of the tumor. Restoration of lymphocyte responses followed not only surgery but partial restoration was also observed after sham surgery. The implications of these findings are discussed.",
author = "Lopez, {Diana M} and Sigel, {M. M.}",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "18",
pages = "305--312",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "5",

}

TY - JOUR

T1 - Correlation of tumor growth and cell mediated immune responses of mice bearing mammary tumors following surgical procedures

AU - Lopez, Diana M

AU - Sigel, M. M.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - Following surgical removal of transplantable mammary tumors some mice remained tumor free, while in others there was a regrowth of tumor. There was a correlation between lymphocyte responses to tumor antigens and mitogens and the clinical course subsequent to surgery. The highest responses occurred in lymphocytes from mice free of tumors or with small tumors. Animals in which tumors regenerated had diminished responses and the degree of diminution corresponded to the size of the tumor. Restoration of lymphocyte responses followed not only surgery but partial restoration was also observed after sham surgery. The implications of these findings are discussed.

AB - Following surgical removal of transplantable mammary tumors some mice remained tumor free, while in others there was a regrowth of tumor. There was a correlation between lymphocyte responses to tumor antigens and mitogens and the clinical course subsequent to surgery. The highest responses occurred in lymphocytes from mice free of tumors or with small tumors. Animals in which tumors regenerated had diminished responses and the degree of diminution corresponded to the size of the tumor. Restoration of lymphocyte responses followed not only surgery but partial restoration was also observed after sham surgery. The implications of these findings are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0016623517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016623517&partnerID=8YFLogxK

M3 - Article

C2 - 1206665

AN - SCOPUS:0016623517

VL - 18

SP - 305

EP - 312

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 5

ER -