Correlation of tumor growth and cell mediated immune responses of mice bearing mammary tumors following surgical procedures

D. M. Lopez, M. M. Sigel

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Following surgical removal of transplantable mammary tumors some mice remained tumor free, while in others there was a regrowth of tumor. There was a correlation between lymphocyte responses to tumor antigens and mitogens and the clinical course subsequent to surgery. The highest responses occurred in lymphocytes from mice free of tumors or with small tumors. Animals in which tumors regenerated had diminished responses and the degree of diminution corresponded to the size of the tumor. Restoration of lymphocyte responses followed not only surgery but partial restoration was also observed after sham surgery. The implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalRES Journal of the Reticuloendothelial Society
Volume18
Issue number5
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Hematology

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