Parental AKR/J, and AKB6F1 and AKD2F1 hybrid mice were injected s.c. with a spontaneously AKR/J tumor. The highly responsive AKB6F1 strain never exhibited any depression of immune functioning during the course of tumor growth and regression. The (AKR/J) intermediately responsive strain, while able to generate a successful antitumor response, did display a transient reduction of immunological capability, but only during the period of tumor growth and not during tumor regression. Cells able to suppress antibody, but not cell mediated responses, were found. The unresponsive AKD2F1 strain was characterized by both a marked depression of immune responsiveness, as well as the generation of suppressor cells to both antibody, and later, cell mediated responses. Depression of immune responsiveness, and the generation of suppressor cells, appeared to correlate with the strength or weakness of the antitumor response in these strains of mice.
ASJC Scopus subject areas
- Immunology and Allergy