Correlation between glucose utilization and metabolite levels during focal ischemia in cat brain

F. A. Welsh, J. H. Greenberg, S. C. Jones, Myron Ginsberg, M. Reivich

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Focal ischemia was produced in cat brain by occluding the middle cerebral artery. After 60 min of ischemia the rate of glucose utilization, as measured by the uptake of [ 14C]deoxyglucose ([ 14C]DG), was correlated with tissue levels of ATP, phosphocreatine, and lactate measured in the same regional samples. Ischemia caused local increases of [ 14C] DG uptake which were associated with mild to moderate anaerobic perturbations of metabolite levels. Altered metabolite levels also occurred in regions in which the rate of glucose consumption was not markedly different from that of the non-ischemic hemisphere. In addition, there were regions with decreased [ 14C] DG uptake which invariably were depleted of ATP and phosphocreatine. Thus, suppression of glucose metabolism was restricted to the most severely ischemic areas, where the delivery of glucose may be rate-limiting.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalStroke
Volume11
Issue number1
StatePublished - Mar 21 1980
Externally publishedYes

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Cats
Ischemia
Glucose
Phosphocreatine
Brain
Adenosine Triphosphate
Deoxyglucose
Middle Cerebral Artery
Lactic Acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Welsh, F. A., Greenberg, J. H., Jones, S. C., Ginsberg, M., & Reivich, M. (1980). Correlation between glucose utilization and metabolite levels during focal ischemia in cat brain. Stroke, 11(1), 79-84.

Correlation between glucose utilization and metabolite levels during focal ischemia in cat brain. / Welsh, F. A.; Greenberg, J. H.; Jones, S. C.; Ginsberg, Myron; Reivich, M.

In: Stroke, Vol. 11, No. 1, 21.03.1980, p. 79-84.

Research output: Contribution to journalArticle

Welsh, FA, Greenberg, JH, Jones, SC, Ginsberg, M & Reivich, M 1980, 'Correlation between glucose utilization and metabolite levels during focal ischemia in cat brain', Stroke, vol. 11, no. 1, pp. 79-84.
Welsh, F. A. ; Greenberg, J. H. ; Jones, S. C. ; Ginsberg, Myron ; Reivich, M. / Correlation between glucose utilization and metabolite levels during focal ischemia in cat brain. In: Stroke. 1980 ; Vol. 11, No. 1. pp. 79-84.
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