Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

Julio A. Chirinos, Juan P. Zambrano, Salim S. Virani, Joaquin J. Jimenez, Wenche Jy, Eugene R Ahn, Lawrence L. Horstman, Agustin Castellanos, Robert J. Myerburg, Yeon S. Ahn

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.

Original languageEnglish (US)
Pages (from-to)1258-1260
Number of pages3
JournalAmerican Journal of Cardiology
Volume95
Issue number10
DOIs
StatePublished - May 15 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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