Abstract
OBJECTIVES:: Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort. METHODS:: We performed a cross-sectional study in children (5-17 years of age, n=86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations. RESULTS:: Body mass index (BMI) had the highest univariate inverse correlation with logeadiponectin (r=-0.5, P<0.0001). In multivariate analysis, BMI remained inversely correlated with logeadiponectin after accounting for age and route of HCV transmission (r=-0.38, P=0.0003). Steatosis and fibrosis were inversely related to logeadiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P≥0.1827). CONCLUSIONS:: High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth.
| Original language | English |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Journal of Pediatric Gastroenterology and Nutrition |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2015 |
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Keywords
- adiponectin
- body mass index
- hepatitis C
- pediatric
ASJC Scopus subject areas
- Gastroenterology
- Pediatrics, Perinatology, and Child Health
Cite this
Correlates of adiponectin in hepatitis C-infected children : The importance of body mass index. / Delgado-Borrego, Aymin; Gonzalez-Peralta, Regino P.; Raza, Roshan; Negre, Betania; Goodman, Zachary D.; Jonas, Maureen M.; Chung, Raymond T.; Ludwig, David.
In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 60, No. 2, 01.01.2015, p. 165-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlates of adiponectin in hepatitis C-infected children
T2 - The importance of body mass index
AU - Delgado-Borrego, Aymin
AU - Gonzalez-Peralta, Regino P.
AU - Raza, Roshan
AU - Negre, Betania
AU - Goodman, Zachary D.
AU - Jonas, Maureen M.
AU - Chung, Raymond T.
AU - Ludwig, David
PY - 2015/1/1
Y1 - 2015/1/1
N2 - OBJECTIVES:: Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort. METHODS:: We performed a cross-sectional study in children (5-17 years of age, n=86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations. RESULTS:: Body mass index (BMI) had the highest univariate inverse correlation with logeadiponectin (r=-0.5, P<0.0001). In multivariate analysis, BMI remained inversely correlated with logeadiponectin after accounting for age and route of HCV transmission (r=-0.38, P=0.0003). Steatosis and fibrosis were inversely related to logeadiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P≥0.1827). CONCLUSIONS:: High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth.
AB - OBJECTIVES:: Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort. METHODS:: We performed a cross-sectional study in children (5-17 years of age, n=86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations. RESULTS:: Body mass index (BMI) had the highest univariate inverse correlation with logeadiponectin (r=-0.5, P<0.0001). In multivariate analysis, BMI remained inversely correlated with logeadiponectin after accounting for age and route of HCV transmission (r=-0.38, P=0.0003). Steatosis and fibrosis were inversely related to logeadiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P≥0.1827). CONCLUSIONS:: High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth.
KW - adiponectin
KW - body mass index
KW - hepatitis C
KW - pediatric
UR - http://www.scopus.com/inward/record.url?scp=84922287664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922287664&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000000604
DO - 10.1097/MPG.0000000000000604
M3 - Article
VL - 60
SP - 165
EP - 170
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 2
ER -