Correlates of adiponectin in hepatitis C-infected children: The importance of body mass index

Aymin Delgado-Borrego, Regino P. Gonzalez-Peralta, Roshan Raza, Betania Negre, Zachary D. Goodman, Maureen M. Jonas, Raymond T. Chung, David Ludwig

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

OBJECTIVES:: Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort. METHODS:: We performed a cross-sectional study in children (5-17 years of age, n=86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations. RESULTS:: Body mass index (BMI) had the highest univariate inverse correlation with logeadiponectin (r=-0.5, P<0.0001). In multivariate analysis, BMI remained inversely correlated with logeadiponectin after accounting for age and route of HCV transmission (r=-0.38, P=0.0003). Steatosis and fibrosis were inversely related to logeadiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P≥0.1827). CONCLUSIONS:: High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume60
Issue number2
DOIs
StatePublished - Jan 1 2015

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Keywords

  • adiponectin
  • body mass index
  • hepatitis C
  • pediatric

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Delgado-Borrego, A., Gonzalez-Peralta, R. P., Raza, R., Negre, B., Goodman, Z. D., Jonas, M. M., Chung, R. T., & Ludwig, D. (2015). Correlates of adiponectin in hepatitis C-infected children: The importance of body mass index. Journal of Pediatric Gastroenterology and Nutrition, 60(2), 165-170. https://doi.org/10.1097/MPG.0000000000000604