Correction of Severe Coagulopathy and Hyperfibrinolysis by Tranexamic Acid and Recombinant Factor VIIa in a Cirrhotic Patient After Trauma: A Case Report

Jack Louro, Katherine Andersen, Roman Dudaryk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Coagulopathy induced by trauma or cirrhosis is a well-recognized entity. Viscoelastic testing has been used in either condition for goal-directed transfusion and detection of fibrinolysis since conventional coagulation tests do not correlate with clinical risk of bleeding. Hemostatic resuscitation may not be adequate for a trauma patient with liver disease due to complex alterations in coagulation systems and occasionally require adjuvant therapy. We report a case of trauma-induced coagulopathy presenting as severe hyperfibrinolysis in a cirrhotic patient who was refractory to hemostatic resuscitation but was rapidly corrected by the administration of tranexamic acid and recombinant Factor VIIa.

Original languageEnglish (US)
Pages (from-to)144-147
Number of pages4
JournalA & A case reports
Volume9
Issue number5
DOIs
StatePublished - Sep 1 2017

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Tranexamic Acid
Hemostatics
Resuscitation
Wounds and Injuries
Fibrinolysis
Liver Diseases
Fibrosis
Hemorrhage
recombinant FVIIa
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Correction of Severe Coagulopathy and Hyperfibrinolysis by Tranexamic Acid and Recombinant Factor VIIa in a Cirrhotic Patient After Trauma : A Case Report. / Louro, Jack; Andersen, Katherine; Dudaryk, Roman.

In: A & A case reports, Vol. 9, No. 5, 01.09.2017, p. 144-147.

Research output: Contribution to journalArticle

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