Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase

R. S. Stack, C. M. O'Connor, D. B. Mark, T. Hinohara, H. R. Phillips, M. M. Lee, N. M. Ramirez, W. G. O'Callaghan, C. A. Simonton, E. B. Carlson, K. G. Morris, V. S. Behar, Y. Kong, R. H. Peter, R. M. Califf

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Abstract

Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% and persistent coronary perfusion after the procedure was achieved in 90% (including 3% with significant residual stenosis). Total in-hospital mortality was 12%. Multivariable analysis showed a higher hospital mortality with cardiogenic shock (41% vs 5% without shock), older age, lower left ventricular ejection fraction, and female sex. Final patency of the infarct-related vessel was determined by follow-up in-hospital cardiac catheterization. Coronary reocclusion occurred in 11% (symptomatic in 7%, treated with emergency angioplasty or bypass surgery; silent in 4%, treated medically). Of the surviving patients with successful initial establishment of infarct vessel patency, 94% were discharged from the hospital with an open infarct artery or a bypass graft to the infarct vessel. There was significant improvement in both ejection fraction (44% to 49%; p < .0001) and regional wall motion in the infarct zone (- 3.0 SD to -2.4 SD; p < .0001) among patients with persistent coronary perfusion and insignificant residual stenosis at the time of the follow-up cardiac catheterization. Thus, a treatment strategy for acute myocardial infarction that includes immediate administration of streptokinase followed by emergency coronary angioplasty, and coronary bypass surgery when necessary, results in a high rate of early and sustained patency of the infarct-related vessel.

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalCirculation
Volume77
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

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Streptokinase
Angioplasty
Emergencies
Perfusion
Myocardial Infarction
Cardiac Catheterization
Hospital Mortality
Pathologic Constriction
Cardiogenic Shock
Stroke Volume
Shock
Therapeutics
Arteries
Transplants

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Stack, R. S., O'Connor, C. M., Mark, D. B., Hinohara, T., Phillips, H. R., Lee, M. M., ... Califf, R. M. (1988). Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase. Circulation, 77(1), 151-161.

Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase. / Stack, R. S.; O'Connor, C. M.; Mark, D. B.; Hinohara, T.; Phillips, H. R.; Lee, M. M.; Ramirez, N. M.; O'Callaghan, W. G.; Simonton, C. A.; Carlson, E. B.; Morris, K. G.; Behar, V. S.; Kong, Y.; Peter, R. H.; Califf, R. M.

In: Circulation, Vol. 77, No. 1, 01.01.1988, p. 151-161.

Research output: Contribution to journalArticle

Stack, RS, O'Connor, CM, Mark, DB, Hinohara, T, Phillips, HR, Lee, MM, Ramirez, NM, O'Callaghan, WG, Simonton, CA, Carlson, EB, Morris, KG, Behar, VS, Kong, Y, Peter, RH & Califf, RM 1988, 'Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase', Circulation, vol. 77, no. 1, pp. 151-161.
Stack, R. S. ; O'Connor, C. M. ; Mark, D. B. ; Hinohara, T. ; Phillips, H. R. ; Lee, M. M. ; Ramirez, N. M. ; O'Callaghan, W. G. ; Simonton, C. A. ; Carlson, E. B. ; Morris, K. G. ; Behar, V. S. ; Kong, Y. ; Peter, R. H. ; Califf, R. M. / Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase. In: Circulation. 1988 ; Vol. 77, No. 1. pp. 151-161.
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abstract = "Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99{\%} and persistent coronary perfusion after the procedure was achieved in 90{\%} (including 3{\%} with significant residual stenosis). Total in-hospital mortality was 12{\%}. Multivariable analysis showed a higher hospital mortality with cardiogenic shock (41{\%} vs 5{\%} without shock), older age, lower left ventricular ejection fraction, and female sex. Final patency of the infarct-related vessel was determined by follow-up in-hospital cardiac catheterization. Coronary reocclusion occurred in 11{\%} (symptomatic in 7{\%}, treated with emergency angioplasty or bypass surgery; silent in 4{\%}, treated medically). Of the surviving patients with successful initial establishment of infarct vessel patency, 94{\%} were discharged from the hospital with an open infarct artery or a bypass graft to the infarct vessel. There was significant improvement in both ejection fraction (44{\%} to 49{\%}; p < .0001) and regional wall motion in the infarct zone (- 3.0 SD to -2.4 SD; p < .0001) among patients with persistent coronary perfusion and insignificant residual stenosis at the time of the follow-up cardiac catheterization. Thus, a treatment strategy for acute myocardial infarction that includes immediate administration of streptokinase followed by emergency coronary angioplasty, and coronary bypass surgery when necessary, results in a high rate of early and sustained patency of the infarct-related vessel.",
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AU - O'Connor, C. M.

AU - Mark, D. B.

AU - Hinohara, T.

AU - Phillips, H. R.

AU - Lee, M. M.

AU - Ramirez, N. M.

AU - O'Callaghan, W. G.

AU - Simonton, C. A.

AU - Carlson, E. B.

AU - Morris, K. G.

AU - Behar, V. S.

AU - Kong, Y.

AU - Peter, R. H.

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N2 - Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% and persistent coronary perfusion after the procedure was achieved in 90% (including 3% with significant residual stenosis). Total in-hospital mortality was 12%. Multivariable analysis showed a higher hospital mortality with cardiogenic shock (41% vs 5% without shock), older age, lower left ventricular ejection fraction, and female sex. Final patency of the infarct-related vessel was determined by follow-up in-hospital cardiac catheterization. Coronary reocclusion occurred in 11% (symptomatic in 7%, treated with emergency angioplasty or bypass surgery; silent in 4%, treated medically). Of the surviving patients with successful initial establishment of infarct vessel patency, 94% were discharged from the hospital with an open infarct artery or a bypass graft to the infarct vessel. There was significant improvement in both ejection fraction (44% to 49%; p < .0001) and regional wall motion in the infarct zone (- 3.0 SD to -2.4 SD; p < .0001) among patients with persistent coronary perfusion and insignificant residual stenosis at the time of the follow-up cardiac catheterization. Thus, a treatment strategy for acute myocardial infarction that includes immediate administration of streptokinase followed by emergency coronary angioplasty, and coronary bypass surgery when necessary, results in a high rate of early and sustained patency of the infarct-related vessel.

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