Coronary heart disease and stroke attributable to major risk factors is similar in Argentina and the United States: The Coronary Heart Disease Policy Model

Andrew Moran, Vincent Degennaro, Daniel Ferrante, Pamela G. Coxson, Walter Palmas, Raul Mejia, Eliseo J. Perez-Stable, Lee Goldman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Cardiovascular disease is the leading cause of death in Argentina and the U.S. Argentina is 92% urban, with cardiovascular disease risk factor levels approximating the U.S. Methods: The Coronary Heart Disease (CHD) Policy Model is a national-scale computer model of CHD and stroke. Risk factor data were obtained from the Cardiovascular Risk Factor Multiple Evaluation in Latin America Study (2003-04), Argentina National Risk Factor Survey (2005) and U.S. national surveys. Proportions of cardiovascular events over 2005-2015 attributable to risk factors were simulated by setting risk factors to optimal exposure levels [systolic blood pressure (SBP) 115 mm Hg, low-density lipoprotein cholesterol (LDL) 2.00 mmol/l (78 mg/dl), high-density lipoprotein cholesterol (HDL) 1.03 mmol/l (60 mg/dl), absence of diabetes, and smoking]. Cardiovascular disease attributable to body mass index (BMI) > 21 kg/m2 was assumed mediated through SBP, LDL, HDL, and diabetes. Results: Cardiovascular disease attributable to major risk factors was similar between Argentina and the U.S., except for elevated SBP in men (CHD 8% points higher in Argentine men, 6% higher for stroke). CHD attributable to BMI > 21 kg/m2 was substantially higher in the U.S. (men 10-11% points higher; women CHD 13-14% higher). Conclusions: Projected cardiovascular disease attributable to major risk factors appeared similar in Argentina and the U.S., though elevated BMI may be responsible for more of U.S. cardiovascular disease. A highly urbanized middle-income nation can have cardiovascular disease rates and risk factor levels comparable to a high income nation, but fewer resources for fighting the epidemic.

Original languageEnglish (US)
Pages (from-to)332-337
Number of pages6
JournalInternational Journal of Cardiology
Volume150
Issue number3
DOIs
StatePublished - Aug 4 2011

Keywords

  • Argentina
  • Coronary heart disease
  • Risk factors
  • Stroke
  • United States

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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