Corneal reshaping and wavefront aberrations during overnight orthokeratology

Yan Lian, Meixiao Shen, Shenghai Huang, Yimin Yuan, Yaozeng Wang, Dexi Zhu, Jun Jiang, Xinjie Mao, Jianhua Wang, Fan Lu

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

PURPOSE:: To investigate changes of corneal thickness at the vertical and horizontal meridians and of wavefront aberrations (WA) over a 30-day period of overnight myopia orthokeratology (OK) lens wear. METHODS:: Sixteen subjects (11 women, 5 men, 26.3±3.2 years) were enrolled and fitted for OK lenses. Long scan depth optical coherence tomography was used to measure corneal thickness profiles at both horizontal and vertical meridians at baseline and on days 1, 7, and 30 days. Corneal and ocular WA of a 6-mm pupil were measured and the root-mean-square (RMS) of the astigmatism, coma, spherical aberration (SA), and total higher-order aberrations (HOAs) were determined. RESULTS:: During the 30-day period, the central cornea thinned in the horizontal and vertical meridians, whereas corneal thickening occurred in the temporal, nasal, and inferior mid-peripheries. In contrast, the cornea thinned in the mid-peripheral superior. There were significant increases in RMS for astigmatism, SA, coma, and positive horizontal coma during the study period. After OK, there were significant positive correlations between the midperipheral-central thickness change difference and the changes in corneal and ocular RMS of total HOAs and SA (r range: 0.281 to 0.492, P<0.05). Only the change of corneal coma RMS was correlated with midperipheral-central thickness change difference (r=0.270, P<0.05). The change in corneal horizontal coma was correlated with the temporal-nasal thickness change difference (r=-0.289, P<0.05). CONCLUSIONS:: Overnight OK caused unique changes in corneal thickness profiles at the vertical and horizontal meridians and increased corneal and ocular HOAs related to corneal reshaping.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalEye and Contact Lens
Volume40
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • Corneal thickness
  • Optical coherence tomography
  • Orthokeratology
  • Wavefront aberrations

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Corneal reshaping and wavefront aberrations during overnight orthokeratology'. Together they form a unique fingerprint.

  • Cite this

    Lian, Y., Shen, M., Huang, S., Yuan, Y., Wang, Y., Zhu, D., Jiang, J., Mao, X., Wang, J., & Lu, F. (2014). Corneal reshaping and wavefront aberrations during overnight orthokeratology. Eye and Contact Lens, 40(3), 161-168. https://doi.org/10.1097/ICL.0000000000000031